The past, present, and future of antibiotics

MA Cook, GD Wright - Science translational medicine, 2022 - science.org
Antibiotics have transformed modern medicine. They are essential for treating infectious
diseases and enable vital therapies and procedures. However, despite this success, their …

[HTML][HTML] Antibiotic resistance in microbes: History, mechanisms, therapeutic strategies and future prospects

TM Uddin, AJ Chakraborty, A Khusro… - Journal of infection and …, 2021 - Elsevier
Antibiotics have been used to cure bacterial infections for more than 70 years, and these low-
molecular-weight bioactive agents have also been used for a variety of other medicinal …

[HTML][HTML] Antimicrobial resistance: Prevalence, economic burden, mechanisms of resistance and strategies to overcome

T Pulingam, T Parumasivam, AM Gazzali… - European Journal of …, 2022 - Elsevier
Antibiotic resistance is a major health concern globally and has been estimated to cause 10
million deaths worldwide by year 2050 if the current trend of inappropriate and excessive …

Drug combinations: a strategy to extend the life of antibiotics in the 21st century

M Tyers, GD Wright - Nature Reviews Microbiology, 2019 - nature.com
Antimicrobial resistance threatens a resurgence of life-threatening bacterial infections and
the potential demise of many aspects of modern medicine. Despite intensive drug discovery …

Extensive impact of non-antibiotic drugs on human gut bacteria

L Maier, M Pruteanu, M Kuhn, G Zeller, A Telzerow… - Nature, 2018 - nature.com
A few commonly used non-antibiotic drugs have recently been associated with changes in
gut microbiome composition, but the extent of this phenomenon is unknown. Here, we …

Targeting the holy triangle of quorum sensing, biofilm formation, and antibiotic resistance in pathogenic bacteria

RV Sionov, D Steinberg - Microorganisms, 2022 - mdpi.com
Chronic and recurrent bacterial infections are frequently associated with the formation of
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …

Antimicrobial activity of some essential oils—present status and future perspectives

S Chouhan, K Sharma, S Guleria - Medicines, 2017 - mdpi.com
Extensive documentation on the antimicrobial properties of essential oils and their
constituents has been carried out by several workers. Although the mechanism of action of a …

Strategies for combating bacterial biofilms: A focus on anti-biofilm agents and their mechanisms of action

R Roy, M Tiwari, G Donelli, V Tiwari - Virulence, 2018 - Taylor & Francis
Biofilm refers to the complex, sessile communities of microbes found either attached to a
surface or buried firmly in an extracellular matrix as aggregates. The biofilm matrix …

Antibacterial drug discovery in the resistance era

ED Brown, GD Wright - Nature, 2016 - nature.com
The looming antibiotic-resistance crisis has penetrated the consciousness of clinicians,
researchers, policymakers, politicians and the public at large. The evolution and widespread …

Antimicrobial hybrid amphiphile via dynamic covalent bonds enables bacterial biofilm dispersal and bacteria eradication

Y Zhan, X Hu, Y Li, Y Wang, H Chen… - Advanced Functional …, 2023 - Wiley Online Library
To tackle the problems caused by bacterial biofilms, herein, this study reports an
antimicrobial hybrid amphiphile (aHA) via dynamic covalent bonds for eradicating …