With the increasing prevalence of type 2 diabetes and fatty liver disease, there is still an
unmet need to better treat hyperglycemia and hyperlipidemia. Here, we identify isthmin-1 …

Isthmin (ISM) is a secreted protein family with two members, namely ISM1 and ISM2, both
containing a TSR1 domain followed by an AMOP domain. Its broad expression pattern …

Abstract Isthmin-1 (ISM1) was initially thought to be a brain secretory factor, but with the
development of technical means of research and the refinement of animal models …

Cytokines are involved in many functions of the immune system including initiating,
amplifying and resolving immune responses. Through bioinformatics analyses of a …

Hypoxia-induced pulmonary microvascular endothelial cell (PMVEC) monolayers
hyperpermeability is vital for vascular leakage, which participates in vascular diseases, such …

Background: An increasing number of studies have shown that Isthmin 1 (ISM1), a secreted
protein, is important in tumorigenesis and invasion, including in colorectal cancer (CRC) …

Purpose This study aimed to investigate the relationship between serum isthmin-1 (ISM1)
and type 2 diabetes mellitus (T2DM), and the alteration of serum ISM1 level in both diabetic …

Purpose To examine the association of serum Ism1, a new adipokine that can regulate
glucose uptake, with type 2 diabetes (T2D) in a Chinese population. Considering high …

Abstract Isthmin 1 (Ism1) has been shown to play roles in multiple biological processes
including morphogenesis, hematopoiesis, antiviral immune response and suppression of …

Introduction Isthmin-1 (Ism-1), as a novel adipokine, plays a role in glucose homeostasis
and lipid metabolism. However, the relationship between Ism-1 and type 2 diabetes mellitus …