Biomarkers of sepsis: time for a reappraisal

C Pierrakos, D Velissaris, M Bisdorff, JC Marshall… - Critical Care, 2020 - Springer
Introduction Sepsis biomarkers can have important diagnostic, therapeutic, and prognostic
functions. In a previous review, we identified 3370 references reporting on 178 different …

Trauma-induced coagulopathy

EE Moore, HB Moore, LZ Kornblith, MD Neal… - Nature reviews Disease …, 2021 - nature.com
Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …

Disseminated intravascular coagulation: epidemiology, biomarkers, and management

K Adelborg, JB Larsen, AM Hvas - British Journal of …, 2021 - Wiley Online Library
Disseminated intravascular coagulation (DIC) is a systemic activation of the coagulation
system, which results in microvascular thrombosis and, simultaneously, potentially life …

Acute fibrinolysis shutdown occurs early in septic shock and is associated with increased morbidity and mortality: results of an observational pilot study

FCF Schmitt, V Manolov, J Morgenstern… - Annals of intensive …, 2019 - Springer
Background Septic coagulopathy represents a very dynamic disease entity, tilting from initial
hypercoagulability towards a subsequent hypocoagulable disease state, entitled overt …

[HTML][HTML] The diagnostic accuracy of procalcitonin for bacteraemia: a systematic review and meta-analysis

SH Hoeboer, PJ van der Geest, D Nieboer… - Clinical Microbiology …, 2015 - Elsevier
The diagnostic use of procalcitonin for bacterial infections remains a matter of debate. Most
studies have used ambiguous outcome measures such as sepsis instead of infection. We …

High D dimers and low global fibrinolysis coexist in COVID19 patients: what is going on in there?

C Ibañez, J Perdomo, A Calvo, C Ferrando… - Journal of thrombosis …, 2021 - Springer
Backgroud COVID-19 coagulopathy linked to increased D-dimer levels has been associated
with high mortality (Fei Z et al. in Clinical course and risk factors for mortality of adult …

COVID-19–associated coagulopathy and inflammatory response: what do we know already and what are the knowledge gaps?

K Goerlinger, D Dirkmann, A Gandhi… - Anesthesia & …, 2020 - journals.lww.com
Patients with coronavirus disease 2019 (COVID-19) frequently experience a coagulopathy
associated with a high incidence of thrombotic events leading to poor outcomes. Here …

Utility of thromboelastography and/or thromboelastometry in adults with sepsis: a systematic review

MC Müller, JCM Meijers, MB Vroom, NP Juffermans - Critical care, 2014 - Springer
Introduction Coagulation abnormalities are frequent in sepsis. Conventional coagulation
assays, however, have several limitations. A surge of interest exists in the use of point-of …

Greater fibrinolysis resistance but no greater platelet aggregation in critically ill COVID-19 patients

C Heinz, W Miesbach, E Herrmann… - …, 2021 - pubs.asahq.org
Background The hemostatic balance in patients with coronavirus disease 2019 (COVID-19)
seems to be shifted toward a hypercoagulable state. The aim of the current study was to …

Revisiting the white blood cell count: immature granulocytes count as a diagnostic marker to discriminate between SIRS and sepsis-a prospective, observational study

A Nierhaus, S Klatte, J Linssen, NM Eismann… - BMC immunology, 2013 - Springer
Background Sepsis is a serious disease condition and a major cause of intensive care unit
(ICU) admission. Its diagnosis in critically ill patients is complicated. To diagnose an …