The ribosome is an ancient molecular fossil that provides a telescope to the origins of life.
Made from RNA and protein, the ribosome translates mRNA to coded protein in all living …

Although antibiotics have long been known to have multiple effects on bacterial cells at low
concentrations, it is only with the advent of genome transcription analyses that these …

Background The mitochondrial (mt) genome has been used as an effective tool for
phylogenetic and population genetic analyses in vertebrates. However, the structure and …

With an increasing interest in RNA therapeutics and for targeting RNA to treat disease, there
is a need for the tools used in protein-based drug design, particularly DOCKing algorithms …

Differences between the structures of bacterial, archaeal, and eukaryotic ribosomes account
for the selective action of antibiotics. Even minor variations in the structure of ribosomes of …

Protein synthesis is one of the major targets in the cell for antibiotics. This review endeavors
to provide a comprehensive “post-ribosome structure” A–Z of the huge diversity of antibiotics …

Six new 5-position modified dUTP derivatives connected by a unique amide linkage were
synthesized and tested for compatibility with the enzymatic steps of in vitro selection. Six …

Research on non‐coding RNA (nc RNA) is a rapidly expanding field. Providing an official
gene symbol and name to nc RNA genes brings order to otherwise potential chaos as it …

Arrest peptides containing RAPP (ArgAlaProPro) motifs have been discovered in both Gram-
positive and Gram-negative bacteria, where they are thought to regulate expression of …

Intracellular levels of reactive oxygen species (ROS) increase as a consequence of
oxidative stress and represent a major source of damage to biomolecules. Due to its high …