Tumor cells reside in a highly complex and heterogeneous tumor microenvironment (TME),
which is composed of a myriad of genetically stable non-cancer cells, including fibroblasts …

The cytoskeleton of animal cells is one of the most complicated and functionally versatile
structures, involved in processes such as endocytosis, cell division, intra-cellular transport …

Simple Summary As our knowledge of cancer as a complex organ comprising tumor cells as
well as surrounding cells within the microenvironment continues to grow, it is imperative to …

CNS tumors remain among the deadliest forms of cancer, resisting conventional and new
treatment approaches, with mortality rates staying practically unchanged over the past 30 …

The preclinical drug screening of pancreatic cancer treatments suffers from the absence of
appropriate models capable to reproduce in vitro the heterogeneous tumor …

Glioblastoma multiforme (GBM), a grade IV astrocytoma, is the most common and deadly
type of primary malignant brain tumor, with a patient's median survival rate ranging from 15 …

Glioblastoma (GBM) is the most prevalent and lethal adult primary central nervous system
cancer. An immunosuppresive and highly heterogeneous tumor microenvironment …

Glioblastoma (GBM) is the most aggressive and common form of primary brain cancer.
Several decades of research have provided great insight into GBM progression; however …

The lack of in vitro models that represent the native tumor microenvironment is a significant
challenge for cancer research. Two-dimensional (2D) monolayer culture has long been the …

Integrins are a large family of transmembrane adhesion receptors, which play a key role in
interactions of a cell with the surrounding stroma. Integrins are comprised of non-covalently …