Metabolism is a dynamic network of biochemical reactions that support systemic
homeostasis amidst changing nutritional, environmental, and physical activity factors. The …

Cells change their metabolism in response to internal and external conditions by regulating
the trans-omic network, which is a global biochemical network with multiple omic layers …

Summary The Curtin-Hammett principle, which works in a reaction sequence where slow
irreversible reactions are connected to a fast reversible reaction, determines the product …

Background Effective drugs for the treatment of hepatic fibrosis have not yet been identified.
Isovitexin (IVT) is a promising hepatoprotective agent owing to its efficacy against acute liver …

Dysregulation of liver metabolism associated with obesity during feeding and fasting leads
to the breakdown of metabolic homeostasis. However, the underlying mechanism remains …

Interactions between various molecular species in biological phenomena give rise to
numerous networks. The investigation of these networks, including their statistical and …

To satisfy both the safety and rapidity of glycemic control, muscles' insulin response must be
bistable, as theoretically predicted. Here, we test the bistability hypothesis by combining …

Elementary flux modes (EFMs) are minimal, steady state pathways characterizing a flux
network. Fundamentally, all steady state fluxes in a network are decomposable into a linear …

Systemic metabolism is regulated by inter-organ communication at the whole-body level,
and at the intra-organ level, there are also numerous factors involved in metabolic …

図 1. トランスオミクスネットワーク.(A) 転写産物・酵素・反応・代謝産物の層にわたるトランス
オミックスネットワーク. 代謝フラックスは反応層のノードの大きさとして表すことができる …