Bidirectional learning in upbound and downbound microzones of the cerebellum

CI De Zeeuw - Nature Reviews Neuroscience, 2021 - nature.com
Over the past several decades, theories about cerebellar learning have evolved. A relatively
simple view that highlighted the contribution of one major form of heterosynaptic plasticity to …

Imaging whole-brain activity to understand behaviour

A Lin, D Witvliet, L Hernandez-Nunez… - Nature Reviews …, 2022 - nature.com
Until now, most brain studies have focused on small numbers of neurons that interact in
limited circuits, allowing analysis of individual computations or steps of neural processing …

High-speed, cortex-wide volumetric recording of neuroactivity at cellular resolution using light beads microscopy

J Demas, J Manley, F Tejera, K Barber, H Kim… - Nature …, 2021 - nature.com
Two-photon microscopy has enabled high-resolution imaging of neuroactivity at depth within
scattering brain tissue. However, its various realizations have not overcome the tradeoffs …

[HTML][HTML] Iterative tomography with digital adaptive optics permits hour-long intravital observation of 3D subcellular dynamics at millisecond scale

J Wu, Z Lu, D Jiang, Y Guo, H Qiao, Y Zhang, T Zhu… - Cell, 2021 - cell.com
Long-term subcellular intravital imaging in mammals is vital to study diverse intercellular
behaviors and organelle functions during native physiological processes. However, optical …

Cognitive-affective functions of the cerebellum

S Rudolph, A Badura, S Lutzu, SS Pathak… - Journal of …, 2023 - Soc Neuroscience
The cerebellum, traditionally associated with motor coordination and balance, also plays a
crucial role in various aspects of higher-order function and dysfunction. Emerging research …

[HTML][HTML] Computational optical sectioning with an incoherent multiscale scattering model for light-field microscopy

Y Zhang, Z Lu, J Wu, X Lin, D Jiang, Y Cai, J Xie… - Nature …, 2021 - nature.com
Quantitative volumetric fluorescence imaging at high speed across a long term is vital to
understand various cellular and subcellular behaviors in living organisms. Light-field …

[HTML][HTML] A brainstem integrator for self-location memory and positional homeostasis in zebrafish

E Yang, MF Zwart, B James, M Rubinov, Z Wei… - Cell, 2022 - cell.com
To track and control self-location, animals integrate their movements through space.
Representations of self-location are observed in the mammalian hippocampal formation, but …

Deep learning-enhanced light-field imaging with continuous validation

N Wagner, F Beuttenmueller, N Norlin, J Gierten… - Nature …, 2021 - nature.com
Visualizing dynamic processes over large, three-dimensional fields of view at high speed is
essential for many applications in the life sciences. Light-field microscopy (LFM) has …

[HTML][HTML] Precise visuomotor transformations underlying collective behavior in larval zebrafish

R Harpaz, MN Nguyen, A Bahl, F Engert - Nature communications, 2021 - nature.com
Complex schooling behaviors result from local interactions among individuals. Yet, how
sensory signals from neighbors are analyzed in the visuomotor stream of animals is poorly …

Regional synapse gain and loss accompany memory formation in larval zebrafish

WP Dempsey, Z Du, A Nadtochiy… - Proceedings of the …, 2022 - National Acad Sciences
Defining the structural and functional changes in the nervous system underlying learning
and memory represents a major challenge for modern neuroscience. Although changes in …