Modeling and simulation of drug disposition has emerged as an important tool in drug
development, clinical study design and regulatory review, and the number of physiologically …

Physiologically‐based pharmacokinetic (PBPK) modeling has been extensively used to
quantitatively translate in vitro data and evaluate temporal effects from drug–drug …

Analyses of drug pharmacokinetics (PKs) and pharmacodynamics (PDs) performed in
animals are often not predictive of drug PKs and PDs in humans, and in vitro PK and PD …

Transporters in the human liver play a major role in the clearance of endo-and xenobiotics.
Apical (canalicular) transporters extrude compounds to the bile, while basolateral …

A reliable translation of in vitro and preclinical data on drug absorption, distribution,
metabolism, and excretion (ADME) to humans is important for safe and effective drug …

This white paper examines recent progress, applications, and challenges in predicting
unbound and total tissue and intra/subcellular drug concentrations using in vitro and …

Systems Toxicology aims to change the basis of how adverse biological effects of
xenobiotics are characterized from empirical end points to describing modes of action as …

Metformin is used as a probe for OCT2 mediated transport when investigating possible DDIs
with new chemical entities. The aim of the current study was to investigate the ability of …

Understanding transporter‐mediated drug disposition and pharmacokinetics (PK) in patients
with nonalcoholic fatty liver disease (NAFLD) is critical in developing treatment options …

Breast cancer resistance protein (BCRP; ABCG2) limits intestinal absorption of low-
permeability substrate drugs and mediates biliary excretion of drugs and metabolites. Based …