Biochemistry and pathology of radical-mediated protein oxidation
Radical-mediated damage to proteins may be initiated by electron leakage, metal-ion-
dependent reactions and autoxidation of lipids and sugars. The consequent protein …
dependent reactions and autoxidation of lipids and sugars. The consequent protein …
State-of-the-Art-Review: the antithrombotic factor singlet oxygen/light (1O2/hv)
TW Stief, J Fareed - Clinical and Applied Thrombosis …, 2000 - journals.sagepub.com
Activated phagocytes (especially polymorpho nuclear granulocytes (PMNs)) by respiratory
oxidative/photonic burst (activation of NADPH-oxidase and myeloper oxidase) generate …
oxidative/photonic burst (activation of NADPH-oxidase and myeloper oxidase) generate …
The blood fibrinolysis/deep-sea analogy: a hypothesis on the cell signals singlet oxygen/photons as natural antithrombotics
TW Stief - Thrombosis research, 2000 - thrombosisresearch.com
The darkness in the human blood vessel system halistaurin, or phialidin [12]), of a MW about
20 might be compared to that of the deep sea. The kDa contains the luciferin coelenterazine …
20 might be compared to that of the deep sea. The kDa contains the luciferin coelenterazine …
Regulation of hemostasis by singlet-oxygen (1ΔO2*)
TW Stief - Current Vascular Pharmacology, 2004 - ingentaconnect.com
Hemostasis is the system of generation and destruction of thrombi. It consists of coagulation
and thrombolysis and has a plasmatic part and a cellular one, the latter being the …
and thrombolysis and has a plasmatic part and a cellular one, the latter being the …
Singlet oxygen (1O2) disrupts platelet aggregates
TW Stief, U Feek, A Ramaswamy, V Kretschmer… - Thrombosis research, 2001 - Elsevier
Introduction: Important mediators of activated polymorphonuclear leukocytes (PMN) are the
oxidants HOCl and chloramine, which generate the nonradical photon-emitting oxidant …
oxidants HOCl and chloramine, which generate the nonradical photon-emitting oxidant …
Singlet oxygen potentiates thrombolysis
TW Stief - Clinical and Applied Thrombosis/Hemostasis, 2007 - journals.sagepub.com
Activated polymorphonuclear neutrophils (PMN) participate in physiologic thrombolysis.
PMN produce large amounts of urokinase (u-PA) and oxidants of the hypochlorite …
PMN produce large amounts of urokinase (u-PA) and oxidants of the hypochlorite …
Singlet oxygen inhibits agonist-induced P-selectin expression and formation of platelet aggregates
Major mediators of activated polymorphonuclear leukocytes (PMN) are the oxidants HOCl
and chloramine, which are a source for the nonradical photon-emitting oxidant singlet …
and chloramine, which are a source for the nonradical photon-emitting oxidant singlet …
In vitro simulation of therapeutic thrombolysis with microtiter plate clot-lysis assay
TW Stief - Clinical and Applied Thrombosis/Hemostasis, 2006 - journals.sagepub.com
Only limited comparable data are available on the clot lysis power of the clinically used
plasminogen activators (PA). Here the PA were used at different clinically relevant …
plasminogen activators (PA). Here the PA were used at different clinically relevant …
Monitoring of plasmin and plasminogen activator activity in blood of patients under fibrinolytic treatment by reteplase
TW Stief, A Richter, R Bünder… - Clinical and applied …, 2006 - journals.sagepub.com
There are no reliable data on plasmin or plasminogen activator (PA) activities in blood of
patients receiving fibrinolytic treatment. This is due to continuing in vitro action of PA after …
patients receiving fibrinolytic treatment. This is due to continuing in vitro action of PA after …
In vitro simulation of therapeutic plasmatic fibrinolysis
TW Stief, R Buinder, A Richter… - Clinical and applied …, 2003 - journals.sagepub.com
One type of therapy for thromboembolism is plasmatic thrombolysis. Several plasminogen
activators (PA) are clinically available, including urokinase (u-PA), tissue plasminogen …
activators (PA) are clinically available, including urokinase (u-PA), tissue plasminogen …