N-Acylhydrazones as drugs
Over the last two decades, N-acylhydrazone (NAH) has been proven to be a very versatile
and promising motif in drug design and medicinal chemistry. Herein, we discuss the current …
and promising motif in drug design and medicinal chemistry. Herein, we discuss the current …
Bioactive 1, 2, 3‐Triazoles: An Account on their Synthesis, Structural Diversity and Biological Applications
L da SM Forezi, CGS Lima, AAP Amaral… - The Chemical …, 2021 - Wiley Online Library
The triazole heterocycle is a privileged scaffold in medicinal chemistry, since its structure is
present in a large number of biologically active molecules, including several drugs currently …
present in a large number of biologically active molecules, including several drugs currently …
Synthesis, crystal structure, hirshfeld surface analysis, DFT calculations, anti-diabetic activity and molecular docking studies of (E)-N'-(5-bromo-2-hydroxybenzylidene) …
K Karrouchi, S Fettach, MM Jotani, A Sagaama… - Journal of Molecular …, 2020 - Elsevier
In this present work, the newly synthesized compound E)-N'-(5-bromo-2-
hydroxybenzylidene) isonicotinohydrazide (2) has been synthesized and characterized by …
hydroxybenzylidene) isonicotinohydrazide (2) has been synthesized and characterized by …
Filtering promiscuous compounds in early drug discovery: is it a good idea?
Highlights•Computational filters for unspecific and promiscuous compounds are being
disseminated in the literature.•Apparent promiscuity of certain chemical scaffolds does not …
disseminated in the literature.•Apparent promiscuity of certain chemical scaffolds does not …
Design, synthesis and various bioactivity of acylhydrazone-containing matrine analogues
W Ni, H Song, L Wang, Y Liu, Q Wang - Molecules, 2023 - mdpi.com
Compounds with acylhydrazone fragments contain amide and imine groups that can act as
electron donors and acceptors, so they are easier to bind to biological targets and thus …
electron donors and acceptors, so they are easier to bind to biological targets and thus …
Isomerization of bioactive acylhydrazones triggered by light or thiols
The acylhydrazone unit is well represented in screening databases used to find ligands for
biological targets, and numerous bioactive acylhydrazones have been reported. However …
biological targets, and numerous bioactive acylhydrazones have been reported. However …
Novel cationic bis (acylhydrazones) as modulators of Epstein–Barr virus immune evasion acting through disruption of interaction between nucleolin and G …
O Reznichenko, A Quillévéré, RP Martins… - European Journal of …, 2019 - Elsevier
Abstract The oncogenic Epstein–Barr virus (EBV) evades the immune system through
limiting the expression of its highly antigenic and essential genome maintenance protein …
limiting the expression of its highly antigenic and essential genome maintenance protein …
Synthesis, crystal structures and CT-DNA/BSA binding properties of Co (III) and Cu (II) complexes with bipyridine Schiff base ligand
L Chang, J Yang, S Lai, X Liu, Z Yang, S Zhao - Inorganica Chimica Acta, 2022 - Elsevier
A novel bipyridine Schiff base ligand C 12 H 9 ClN 4 O (HL) and its two transition metal
complexes [CoL 2] NO 3⋅ H 2 O (1) and CuL 2⋅ CH 3 OH (2) have been synthesized. Their …
complexes [CoL 2] NO 3⋅ H 2 O (1) and CuL 2⋅ CH 3 OH (2) have been synthesized. Their …
Potent hydrazone derivatives targeting esophageal cancer cells
LY Li, JD Peng, W Zhou, H Qiao, X Deng, ZH Li… - European Journal of …, 2018 - Elsevier
Hydrazone and their derivatives are a series of highly active molecules, which are widely
used as lead compounds for the research and development of new anti-cancer drugs. In this …
used as lead compounds for the research and development of new anti-cancer drugs. In this …
Structural design, synthesis and substituent effect of hydrazone-N-acylhydrazones reveal potent immunomodulatory agents
CS Meira, JM dos Santos Filho, CC Sousa… - Bioorganic & medicinal …, 2018 - Elsevier
(Nitrophenyl) hydrazone derivatives of N-acylhydrazone were synthesized and screened for
suppress lymphocyte proliferation and nitrite inhibition in macrophages. Compared to an …
suppress lymphocyte proliferation and nitrite inhibition in macrophages. Compared to an …