Patients with acute myeloid leukaemia who relapse following therapy have few treatment
options and face poor outcomes. Immune checkpoint inhibition, for example, by antibody …

Chimeric proteins composed of a biologically active peptide and a fragment crystallizable
(Fc) domain of immunoglobulin G (IgG) are known as peptibodies. They present an …

The eukaryotic replicative helicase CMG is a closed ring around double-stranded (ds) DNA
at origins yet must transition to single-stranded (ss) DNA for helicase action. CMG must also …

Protein immobilization is an essential method for both basic and applied research for
protein, and covalent, site-specific attachment is the most desirable strategy. Classic …

Single-molecule tweezers, such as magnetic tweezers, are powerful tools for probing nm-
scale structural changes in single membrane proteins under force. However, the weak …

Helicases are a broad family of enzymes that perform crucial functions in DNA replication
and in the maintenance of DNA and RNA integrity. A detailed mechanical study of helicases …

Condensin, a conserved member of the SMC protein family of ring‐shaped multi‐subunit
protein complexes, is essential for structuring and compacting chromosomes. Despite its key …

Organoids are transformative in vitro model systems that mimic features of the
corresponding tissue in vivo. However, across tissue types and species, organoids still often …

The human telomeric DNA 3′ single-stranded overhang comprises tandem repeats of the
sequence d (TTAGGG), which can fold into the stable secondary structure G-quadruplex …

The current opioid epidemic is one of the most profound public health crises facing the
United States. Despite that it has been under the spotlight for years, available treatments for …