This Review explores the class of plant-derived macrocyclic peptides called cyclotides. We
include an account of their discovery, characterization, and distribution in the plant kingdom …

The cystine knot structural motif is present in peptides and proteins from a variety of species,
including fungi, plants, marine molluscs, insects and spiders. It comprises an embedded ring …

Several macrocyclic peptides (∼ 30 amino acids), with diverse biological activities, have
been isolated from the Rubiaceae and Violaceae plant families over recent years. We have …

The cyclotides constitute a recently discovered family of plant-derived peptides that have the
unusual features of a head-to-tail cyclized backbone and a cystine knot core. These features …

Several members of the Rubiaceae and Violaceae families produce a series of cyclotides or
macrocyclic peptides of 29–31 amino acids with an embedded cystine knot. We aim to …

We define plant cyclopeptides [with the exception of the acyclic compounds lasiodine-A (1),
13 sanjoinine-G2 (2), 74 astin-J (216), 156 asternin-AC (217-219), 157 and MCoTI-III (462) …

Three trypsin inhibitors (TIs), from the seeds of the squash Momordica cochinchinensis
(MCo), have been isolated and purified using gel filtration, ion exchange chromatography …

In recent years an increasing number of miniproteins containing an amide-cyclized
backbone have been discovered. The cyclotide family is the largest group of such proteins …

Cytotoxic activities of three naturally occurring macrocyclic peptides (cyclotides) isolated
from the two violets, Viola arvensis Murr. and Viola odorata L., were investigated. A …

Circular proteins are a recently discovered phenomenon. They presumably evolved to
confer advantages over ancestral linear proteins while maintaining the intrinsic biological …