DNA repair pathways as guardians of the genome: Therapeutic potential and possible prognostic role in hematologic neoplasms
E Rahimian, A Amini, F Alikarami, SMS Pezeshki… - DNA repair, 2020 - Elsevier
DNA repair pathways, which are also identified as guardians of the genome, protect cells
from frequent damage that can lead to DNA breaks. The most deleterious types of damage …
from frequent damage that can lead to DNA breaks. The most deleterious types of damage …
NBN gene polymorphisms and cancer susceptibility: a systemic review
F Berardinelli, A di Masi, A Antoccia - Current genomics, 2013 - ingentaconnect.com
The relationship between DNA repair failure and cancer is well established as in the case of
rare, high penetrant genes in high cancer risk families. Beside this, in the last two decades …
rare, high penetrant genes in high cancer risk families. Beside this, in the last two decades …
Functional variants in NBS1 and cancer risk: evidence from a meta-analysis of 60 publications with 111 individual studies
P Gao, N Ma, M Li, QB Tian, DW Liu - Mutagenesis, 2013 - academic.oup.com
Several potentially functional variants of Nijmegen breakage syndrome 1 (NBS1) have been
implicated in cancer risk, but individually studies showed inconclusive results. In this study, a …
implicated in cancer risk, but individually studies showed inconclusive results. In this study, a …
Contribution of double-strand break repair gene Nijmegen breakage syndrome 1 genotypes, gender difference and smoking status to Taiwanese lung cancer
CL Chuang, CH Wang, CH Hsu, CL Hsiao… - Anticancer …, 2017 - ar.iiarjournals.org
Background/Aim: Nijmegen breakage syndrome 1 (NBS1) is a component of
MRE11/RAD50/NBS1 complex (MRN) that plays a critical role in the cellular response to …
MRE11/RAD50/NBS1 complex (MRN) that plays a critical role in the cellular response to …
The hMLH1 −93G>A Polymorphism and Risk of Ovarian Cancer in the Chinese Population
L Niu, S Li, H Liang, H Li - PloS one, 2015 - journals.plos.org
Background As a mismatch repair (MMR) gene, hMLH1 plays an important role in the
maintenance of chromosomal integrity. Several studies have investigated the associations of …
maintenance of chromosomal integrity. Several studies have investigated the associations of …
NBS1 Glu185Gln polymorphism and cancer risk: update on current evidence
YZ He, XS Chi, YC Zhang, XB Deng, JR Wang, WY Lv… - Tumor Biology, 2014 - Springer
A number of studies have investigated the association between NBS1 Glu185Gln
(rs1805794, E185Q) polymorphism and cancer risk, but the results remained controversial …
(rs1805794, E185Q) polymorphism and cancer risk, but the results remained controversial …
[HTML][HTML] Homologous recombination repair polymorphisms and the risk for osteosarcoma
K Goričar, V Kovač, J Jazbec, J Lamovec… - Journal of medical …, 2015 - ncbi.nlm.nih.gov
Background DNA repair mechanisms are essential for maintaining genome stability, and
genetic variability in DNA repair genes may contribute to cancer susceptibility. Our aim was …
genetic variability in DNA repair genes may contribute to cancer susceptibility. Our aim was …
Genetic Variation in the 3'-Untranslated Region of NBN Gene Is Associated with Gastric Cancer Risk in a Chinese Population
P Sun, J Du, X Zhu, C Ren, L Xie, N Dai, Y Gu, C Yan… - PloS one, 2015 - journals.plos.org
NBN plays a crucial role in carcinogenesis as a core component for both homologous
recombination (HR) and non-homologous end-joining (NHEJ) DNA double-strand breaks …
recombination (HR) and non-homologous end-joining (NHEJ) DNA double-strand breaks …
An Approach to Elucidate NBS1 Function in DNA Repair Using Frequent Nonsynonymous Polymorphism in Wild Medaka (Oryzias latipes) Populations
K Igarashi, J Kobayashi, T Katsumura, Y Urushihara… - Plos one, 2017 - journals.plos.org
Nbs1 is one of the genes responsible for Nijmegen breakage syndrome, which is marked
with high radiosensitivity. In human NBS1 (hNBS1), Q185E polymorphism is known as the …
with high radiosensitivity. In human NBS1 (hNBS1), Q185E polymorphism is known as the …
A non-synonymous polymorphism in NBS1 is associated with progression from chronic hepatitis B virus infection to hepatocellular carcinoma in a Chinese population
Y Zhen, R Xiao, X Chen, C Yuan, Y Sun… - OncoTargets and …, 2018 - Taylor & Francis
Purpose Nijmegen breakage syndrome 1 (NBS1) has a vital role in DNA double-strand
break (DSB) repair, functioning as a sensor to identify and repair DNA damage and …
break (DSB) repair, functioning as a sensor to identify and repair DNA damage and …