Exogenous chemicals have been implicated in causing mutations that are responsible for
the initiation and progression of tumors (1r5). Mutations in the p53 gene, a tumor suppressor …

Carcinogens are generally mutagens, which is understandable given that tumor cells grow
uncontrollably because they have mutations in critical genes involved in growth control …

Abstract Background: Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in
combustion products of organic matter, including cigarette smoke. Metabolically activated …

DNA lesion bypass is an important cellular response to genomic damage during replication.
Human DNA polymerase η (Polη), encoded by the Xeroderma pigmentosum variant (XPV) …

DNA-protein cross-links (DPCs) present a formidable obstacle to cellular processes
because they are" superbulky" compared with the majority of chemical adducts. Elimination …

Several recently discovered human DNA polymerases are associated with translesion
synthesis past DNA adducts. These include human DNA polymerase κ (pol κ), a homologue …

Abstract p53 mutations are etiologically associated with the development of oral squamous
cell carcinomas (OSCCs) or are associated with exposure to specific carcinogens. In this …

The genome and its nucleotide precursor pool are under sustained attack by radiation,
reactive oxygen and nitrogen species, chemical carcinogens, hydrolytic reactions, and …

In cells, the major benzo [a] pyrene DNA adduct is the highly mutagenic (+)-trans-anti-BPDE-
N2-dG. In eukaryotes, little is known about lesion bypass of this DNA adduct during …

The main achievements in the DNA adduct field in the 1990s have been technical
innovations of methods for specific adducts reaching sensitivities required for low levels …