Because of the high demand of organs, the usage of marginal grafts has increased. These
marginal organs have a higher risk of developing ischemia-reperfusion injury, which can …

Background Liver transplantation is the only curative treatment option for end-stage liver
disease; however, its use remains limited due to a shortage of suitable organs. In recent …

Organ gene therapy represents a promising tool to correct diseases or improve graft survival
after transplantation. Polymorphic variation of the major histocompatibility complex (MHC) …

Cardiac transplantation is the gold standard for treatment for select patients with end-stage
heart failure, yet donor supply is limited. Ex vivo machine perfusion is an emerging …

Despite the advancements in medical treatment, mechanical support, and stem cell therapy,
heart transplantation remains the most effective treatment for selected patients with …

Background For 50 years, static cold storage (SCS) has been the gold standard for solid
organ preservation in transplantation. Although logistically convenient, this preservation …

Transplantation, the gold standard intervention for organ failure, is a clinical field that is ripe
for applications of gene therapy. One of the major challenges in applying gene therapy to …

Ex situ organ preservation by machine perfusion can improve preservation of organs for
transplantation. Furthermore, machine perfusion opens up the possibilities for selective …

Due to higher vulnerability and immunogenicity of extended criteria donor (ECD) organs
used for organ transplantation (Tx), the discovery of new treatment strategies, involving …

This Review examines the state-of-the-art in the delivery of nucleic acid therapies that are
directed to the vascular endothelium. First, we review the most important homeostatic …