The mechanosensory neurons of touch and their mechanisms of activation

A Handler, DD Ginty - Nature Reviews Neuroscience, 2021 - nature.com
Our sense of touch emerges from an array of mechanosensory structures residing within the
fabric of our skin. These tactile end organ structures convert innocuous forces acting on the …

The sensory neurons of touch

VE Abraira, DD Ginty - neuron, 2013 - cell.com
The somatosensory system decodes a wide range of tactile stimuli and thus endows us with
a remarkable capacity for object recognition, texture discrimination, sensory-motor feedback …

The gentle touch receptors of mammalian skin

A Zimmerman, L Bai, DD Ginty - Science, 2014 - science.org
The skin is our largest sensory organ, transmitting pain, temperature, itch, and touch
information to the central nervous system. Touch sensations are conveyed by distinct …

Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors

S Maksimovic, M Nakatani, Y Baba, AM Nelson… - Nature, 2014 - nature.com
Touch submodalities, such as flutter and pressure, are mediated by somatosensory afferents
whose terminal specializations extract tactile features and encode them as action potential …

[HTML][HTML] The functional organization of cutaneous low-threshold mechanosensory neurons

L Li, M Rutlin, VE Abraira, C Cassidy, L Kus, S Gong… - Cell, 2011 - cell.com
Innocuous touch of the skin is detected by distinct populations of neurons, the low-threshold
mechanoreceptors (LTMRs), which are classified as Aβ-, Aδ-, and C-LTMRs. Here, we report …

The cellular and molecular basis of somatosensory neuron development

S Meltzer, C Santiago, N Sharma, DD Ginty - Neuron, 2021 - cell.com
Primary somatosensory neurons convey salient information about our external environment
and internal state to the CNS, allowing us to detect, perceive, and react to a wide range of …

Molecular mechanisms of mechanotransduction in mammalian sensory neurons

P Delmas, J Hao, L Rodat-Despoix - Nature Reviews Neuroscience, 2011 - nature.com
The somatosensory system mediates fundamental physiological functions, including the
senses of touch, pain and proprioception. This variety of functions is matched by a diverse …

Merkel cells are essential for light-touch responses

SM Maricich, SA Wellnitz, AM Nelson, DR Lesniak… - Science, 2009 - science.org
The peripheral nervous system detects different somatosensory stimuli, including pain,
temperature, and touch. Merkel cell-neurite complexes are touch receptors composed of …

The cellular and molecular basis of direction selectivity of Aδ-LTMRs

M Rutlin, CY Ho, VE Abraira, C Cassidy, L Bai… - Cell, 2014 - cell.com
The perception of touch, including the direction of stimulus movement across the skin,
begins with activation of low-threshold mechanosensory neurons (LTMRs) that innervate the …

The benefit of combined acupuncture and antidepressant medication for depression: a systematic review and meta-analysis

YY Chan, WY Lo, SN Yang, YH Chen, JG Lin - Journal of Affective …, 2015 - Elsevier
Acupuncture, one of the most popular complementary therapies, is best known for its ability
to provide pain relief. Accumulating evidence suggests that acupuncture may also be …