Therapy-induced senescence: an “old” friend becomes the enemy

T Saleh, S Bloukh, VJ Carpenter, E Alwohoush… - Cancers, 2020 - mdpi.com
For the past two decades, cellular senescence has been recognized as a central component
of the tumor cell response to chemotherapy and radiation. Traditionally, this form of …

Small molecule compounds that induce cellular senescence

NV Petrova, AK Velichko, SV Razin, OL Kantidze - Aging Cell, 2016 - Wiley Online Library
To date, dozens of stress‐induced cellular senescence phenotypes have been reported.
These cellular senescence states may differ substantially from each other, as well as from …

New visions on natural products and cancer therapy: autophagy and related regulatory pathways

A Martelli, M Omrani, M Zarghooni, V Citi, S Brogi… - Cancers, 2022 - mdpi.com
Simple Summary In the past few years, clinical as well as regular scientists have been
paying attention to medicinal applications of natural products. There are several …

Therapy-induced senescence as a component of tumor biology: Evidence from clinical cancer

T Saleh, S Bloukh, M Hasan, S Al Shboul - Biochimica et Biophysica Acta …, 2023 - Elsevier
Abstract Therapy-Induced Senescence (TIS) is an established response to anticancer
therapy in a variety of cancer models. Ample evidence has characterized the triggers …

Fungal endophytes: an accessible source of bioactive compounds with potential anticancer activity

N Rai, P Gupta, PK Keshri, A Verma, P Mishra… - Applied Biochemistry …, 2022 - Springer
Endophytes either be bacteria, fungi, or actinomycetes colonize inside the tissue of host
plants without showing any immediate negative effects on them. Among numerous natural …

Phytochemicals as potent modulators of autophagy for cancer therapy

MA Moosavi, A Haghi, M Rahmati, H Taniguchi… - Cancer Letters, 2018 - Elsevier
The dysregulation of autophagy is involved in the pathogenesis of a broad range of
diseases, and accordingly universal research efforts have focused on exploring novel …

Effects of irradiance on UVA-induced skin aging

CCE Lan, YT Hung, AH Fang… - Journal of Dermatological …, 2019 - Elsevier
Abstract Background Ultraviolet A (UVA) radiation is the most relevant component of solar
radiation-induced skin aging. Sunscreens were used to minimize the harmful effects of UV …

Oxidative stress mediated by lipid metabolism contributes to high glucose-induced senescence in retinal pigment epithelium

Q Chen, LI Tang, G Xin, S Li, L Ma, Y Xu… - Free Radical Biology …, 2019 - Elsevier
Retinal pigment epithelium (RPE) dysfunction is thought to increase the risk of the
development and progression of diabetic retinopathy (DR), the leading cause of blindness …

Autophagy and senescence in cancer therapy

NH Patel, S Bloukh, E Alwohosh, A Alhesa… - Advances in cancer …, 2021 - Elsevier
Tumor cells can undergo diverse responses to cancer therapy. While apoptosis represents
the most desirable outcome, tumor cells can alternatively undergo autophagy and …

[HTML][HTML] Adaptive response of resistant cancer cells to chemotherapy

YJ Chern, IT Tai - Cancer Biology & Medicine, 2020 - ncbi.nlm.nih.gov
Despite advances in cancer therapeutics and the integration of personalized medicine, the
development of chemoresistance in many patients remains a significant contributing factor to …