Therapy-induced senescence: an “old” friend becomes the enemy
T Saleh, S Bloukh, VJ Carpenter, E Alwohoush… - Cancers, 2020 - mdpi.com
For the past two decades, cellular senescence has been recognized as a central component
of the tumor cell response to chemotherapy and radiation. Traditionally, this form of …
of the tumor cell response to chemotherapy and radiation. Traditionally, this form of …
Small molecule compounds that induce cellular senescence
To date, dozens of stress‐induced cellular senescence phenotypes have been reported.
These cellular senescence states may differ substantially from each other, as well as from …
These cellular senescence states may differ substantially from each other, as well as from …
New visions on natural products and cancer therapy: autophagy and related regulatory pathways
Simple Summary In the past few years, clinical as well as regular scientists have been
paying attention to medicinal applications of natural products. There are several …
paying attention to medicinal applications of natural products. There are several …
Therapy-induced senescence as a component of tumor biology: Evidence from clinical cancer
T Saleh, S Bloukh, M Hasan, S Al Shboul - Biochimica et Biophysica Acta …, 2023 - Elsevier
Abstract Therapy-Induced Senescence (TIS) is an established response to anticancer
therapy in a variety of cancer models. Ample evidence has characterized the triggers …
therapy in a variety of cancer models. Ample evidence has characterized the triggers …
Fungal endophytes: an accessible source of bioactive compounds with potential anticancer activity
Endophytes either be bacteria, fungi, or actinomycetes colonize inside the tissue of host
plants without showing any immediate negative effects on them. Among numerous natural …
plants without showing any immediate negative effects on them. Among numerous natural …
Phytochemicals as potent modulators of autophagy for cancer therapy
MA Moosavi, A Haghi, M Rahmati, H Taniguchi… - Cancer Letters, 2018 - Elsevier
The dysregulation of autophagy is involved in the pathogenesis of a broad range of
diseases, and accordingly universal research efforts have focused on exploring novel …
diseases, and accordingly universal research efforts have focused on exploring novel …
Effects of irradiance on UVA-induced skin aging
CCE Lan, YT Hung, AH Fang… - Journal of Dermatological …, 2019 - Elsevier
Abstract Background Ultraviolet A (UVA) radiation is the most relevant component of solar
radiation-induced skin aging. Sunscreens were used to minimize the harmful effects of UV …
radiation-induced skin aging. Sunscreens were used to minimize the harmful effects of UV …
Oxidative stress mediated by lipid metabolism contributes to high glucose-induced senescence in retinal pigment epithelium
Q Chen, LI Tang, G Xin, S Li, L Ma, Y Xu… - Free Radical Biology …, 2019 - Elsevier
Retinal pigment epithelium (RPE) dysfunction is thought to increase the risk of the
development and progression of diabetic retinopathy (DR), the leading cause of blindness …
development and progression of diabetic retinopathy (DR), the leading cause of blindness …
Autophagy and senescence in cancer therapy
Tumor cells can undergo diverse responses to cancer therapy. While apoptosis represents
the most desirable outcome, tumor cells can alternatively undergo autophagy and …
the most desirable outcome, tumor cells can alternatively undergo autophagy and …
[HTML][HTML] Adaptive response of resistant cancer cells to chemotherapy
YJ Chern, IT Tai - Cancer Biology & Medicine, 2020 - ncbi.nlm.nih.gov
Despite advances in cancer therapeutics and the integration of personalized medicine, the
development of chemoresistance in many patients remains a significant contributing factor to …
development of chemoresistance in many patients remains a significant contributing factor to …