Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications
CC Jiang, LS Lin, S Long, XY Ke, K Fukunaga… - Signal transduction and …, 2022 - nature.com
Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …
A synaptic perspective of fragile X syndrome and autism spectrum disorders
C Bagni, RS Zukin - Neuron, 2019 - cell.com
Altered synaptic structure and function is a major hallmark of fragile X syndrome (FXS),
autism spectrum disorders (ASDs), and other intellectual disabilities (IDs), which are …
autism spectrum disorders (ASDs), and other intellectual disabilities (IDs), which are …
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
Here we conducted a large-scale genetic association analysis of educational attainment in a
sample of approximately 1.1 million individuals and identify 1,271 independent genome …
sample of approximately 1.1 million individuals and identify 1,271 independent genome …
Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment
INTRODUCTION Current views of human evolution, as supported by the fossil record,
indicate that many hominin lineage branches arose, but only one survived to the present …
indicate that many hominin lineage branches arose, but only one survived to the present …
Revealing nanostructures in brain tissue via protein decrowding by iterative expansion microscopy
Many crowded biomolecular structures in cells and tissues are inaccessible to labelling
antibodies. To understand how proteins within these structures are arranged with nanoscale …
antibodies. To understand how proteins within these structures are arranged with nanoscale …
Synaptopathology involved in autism spectrum disorder
Autism spectrum disorder (ASD) encompasses a group of multifactorial neurodevelopmental
disorders characterized by impaired social communication, social interaction and repetitive …
disorders characterized by impaired social communication, social interaction and repetitive …
Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice
B Guo, J Chen, Q Chen, K Ren, D Feng, H Mao… - Nature …, 2019 - nature.com
Social deficit is a core clinical feature of autism spectrum disorder (ASD) but the underlying
neural mechanisms remain largely unclear. We demonstrate that structural and functional …
neural mechanisms remain largely unclear. We demonstrate that structural and functional …
The ASD Living Biology: from cell proliferation to clinical phenotype
E Courchesne, T Pramparo, VH Gazestani… - Molecular …, 2019 - nature.com
Autism spectrum disorder (ASD) has captured the attention of scientists, clinicians and the
lay public because of its uncertain origins and striking and unexplained clinical …
lay public because of its uncertain origins and striking and unexplained clinical …
Dendritic structural plasticity and neuropsychiatric disease
MP Forrest, E Parnell, P Penzes - Nature Reviews Neuroscience, 2018 - nature.com
The structure of neuronal circuits that subserve cognitive functions in the brain is shaped
and refined throughout development and into adulthood. Evidence from human and animal …
and refined throughout development and into adulthood. Evidence from human and animal …
Autism spectrum disorder-like behavior caused by reduced excitatory synaptic transmission in pyramidal neurons of mouse prefrontal cortex
H Sacai, K Sakoori, K Konno, K Nagahama… - Nature …, 2020 - nature.com
Autism spectrum disorder (ASD) is thought to result from deviation from normal development
of neural circuits and synaptic function. Many genes with mutation in ASD patients have …
of neural circuits and synaptic function. Many genes with mutation in ASD patients have …