Diseases intrinsic to the pancreas such as pancreatitis, pancreatic cancer and type 1
diabetes mellitus impart substantial health and financial burdens on society but identification …

Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related mortality in
the United States and has only recently achieved a 5-yr survival rate of 10%. This dismal …

Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease resulting from a complex
interplay between genetic susceptibility and environmental factors. Regarding the latter, gut …

Highlights•Host control over electron acceptor availability generates longitudinal
heterogeneity.•Electron acceptor availability dictates which redox reactions are most …

An imbalance in the microbiota may contribute to many human illnesses, which has
prompted efforts to rebalance it by targeting the microbes themselves. However, by …

Multidrug resistance has become a global health problem associated with high morbidity
and mortality. Antimicrobial peptides have been acknowledged as potential leads for …

Previous studies revealed that caspase recruitment domain protein 9 (CARD9) was involved
in severe acute pancreatitis (SAP) inflammation and that interfering with its expression in …

Type 1 diabetes has an increasingly greater incidence and prevalence with no cure
available. Vitamin D supplementation is well documented to reduce the risk of developing …

Multiple pathways contribute to the pathophysiological development of type 1 diabetes
(T1D); however, the exact mechanisms involved are unclear. We performed differential gene …

Abstract Aims/Hypothesis Defensins play a crucial role in the innate immune system's first
defense against microbial threats. However, little is known about the defensin system in the …