Metabolism generally transforms xenobiotics into more polar and hydrophilic products,
facilitating their elimination from the body. Recently, a new metabolic pathway that …

Abstract Cytochrome P450 (CYP) 3A is an important drug-metabolizing enzyme in humans.
Assessing CYP3A activity is necessary for predicting therapeutic outcomes or the potential …

Abstract UDP-glucuronosyltransferase (UGT) 1A1, one of the most important isoforms in
UGTs superfamily, has attracted increasing concerns for its special role in the clearance and …

Motivation The metabolites of exogenous and endogenous compounds play a pivotal role in
the domain of metabolism research. However, they are still unclear for most chemicals in our …

Endothelin-1 receptors (ETAR and ETBR) act as a pivotal regulator in the biological effects
of ET-1 and represent a potential drug target for the treatment of multiple cardiovascular …

Abstract Cytochrome P450 (CYP) 3A enzymes, the most important phase 1 drug-
metabolizing enzymes, are responsible for 50% of the metabolism of clinically used drugs …

Long-term exposure to estrogens seriously increases the incidence of various diseases
including breast cancer. Experimental studies indicate that cytochrome P450 (CYP) …

During the past decades, there have been continuous attempts in the prediction of
metabolism mediated by cytochrome P450s (CYP450s) 3A4, 2D6, and 2C9. However, it has …

Although it has been proposed for decades to predict site of metabolism (SOM) by in silico
methods, identifying SOM correctly remains an unsolved fundamental problem and is an …

目的考察香芹酚对细胞色素P450 酶3A4 (CYP3A4) 介导的睾酮6β 羟化反应和卡马西平10, 11
环氧化反应的抑制作用. 方法人肝微粒体与香芹酚(或阳性对照酮康唑), 探针底物(睾酮或卡马 …