Homology modelling has matured into an important technique in structural biology,
significantly contributing to narrowing the gap between known protein sequences and …

Viruses are obligate intracellular pathogens that are dependent on cellular machineries for
their replication. Recent technological breakthroughs have facilitated reliable identification …

Accumulation of α-synuclein into toxic oligomers or fibrils is implicated in dopaminergic
neurodegeneration in Parkinson's disease. Here we performed a high-throughput, proteome …

Protein–protein interactions (PPIs) are vital to all biological processes. These interactions
are often dynamic, sometimes transient, typically occur over large topographically shallow …

Over 40% of proteins in any eukaryotic genome encode intrinsically disordered regions (IDR
s) that do not adopt defined tertiary structures. Certain IDR s perform critical functions, but …

Protein-protein interactions are fundamental for virtually all functions of the cell. A large
fraction of these interactions involve short peptide motifs, and there has been increased …

Background: Metastatic disease is a major cause of thyroid cancer-related death. However,
the mechanisms responsible for thyroid cancer metastasis are unclear. Dipeptidyl peptidase …

The calmodulin-binding transcription activator (CAMTA) is a family of transcriptional factors
containing a cluster of calmodulin-binding proteins that can activate gene regulation in …

Emerging protein–protein interaction (PPI) modulators have brought out exciting ability as
therapeutics in human diseases, but its clinical translation has been greatly hampered by …

Therapeutics targeting cytokines such as the oncostatin M (OSM)-mediated inflammation
represent a potential strategy for the treatment of inflammatory bowel disease (IBD). Despite …