Branching ionizable lipids can enhance the stability, fusogenicity, and functional delivery of mRNA

K Hashiba, Y Sato, M Taguchi, S Sakamoto… - Small …, 2023 - Wiley Online Library
Ionizable lipids with branched tails have been used in lipid nanoparticles (LNPs)‐based
messenger RNA (mRNA) therapeutics like COVID‐19 vaccines. However, due to the limited …

A vesicle microrheometer for high-throughput viscosity measurements of lipid and polymer membranes

HA Faizi, R Dimova, PM Vlahovska - Biophysical Journal, 2022 - cell.com
Viscosity is a key property of cell membranes that controls mobility of embedded proteins
and membrane remodeling. Measuring it is challenging because existing approaches …

Julolidine-based Fluorescent Molecular Rotor: Versatile Tool for Sensing and Diagnose

N Chakraborty, A Silswal, AL Koner - Sensors & Diagnostics, 2024 - pubs.rsc.org
Fluorescent molecular rotors incorporating julolidine have found diverse applications in
various fields. Recently, researchers have explored their utility in polymerization, metal ion …

[HTML][HTML] Analytical techniques for the characterization of nanoparticles for mRNA delivery

SS Nogueira, E Samaridou, J Simon, S Frank… - European Journal of …, 2024 - Elsevier
Nanotechnology-assisted RNA delivery has gotten a tremendous boost over the last decade
and made a significant impact in the development of life-changing vaccines and …

Protein crowding and cholesterol increase cell membrane viscosity in a temperature dependent manner

B Fábián, I Vattulainen… - Journal of Chemical Theory …, 2023 - ACS Publications
Shear viscosity of lipid membranes dictates how fast lipids, proteins, and other membrane
constituents travel along the membrane and rotate around their principal axis, thus …

[HTML][HTML] Effect of invasome composition on membrane fluidity, vesicle stability and skin interactions

IVN Cunha, AM Campos, AP Gerola, T Caon - International Journal of …, 2023 - Elsevier
Invasomes have been widely exploited to enhance the percutaneous permeation of drugs.
On the other hand, few studies have been dedicated to evaluating how their composition …

Can Urea and Trimethylamine-N-oxide Prevent the Pressure-Induced Phase Transition of Lipid Membrane?

A Maiti, S Daschakraborty - The Journal of Physical Chemistry B, 2022 - ACS Publications
Organisms dwelling in ocean trenches are exposed to the high hydrostatic pressure of
ocean water. Increasing pressure can alter the membrane packing density and fluidity and …

How Do Urea and Trimethylamine N-Oxide Influence the Dehydration-Induced Phase Transition of a Lipid Membrane?

A Maiti, S Daschakraborty - The Journal of Physical Chemistry B, 2021 - ACS Publications
Living organisms are often exposed to extreme dehydration, which is detrimental to the
structure and function of the cell membrane. The lipid membrane undergoes fluid-to-gel …

Surface viscosities of lipid bilayers determined from equilibrium molecular dynamics simulations

JE Fitzgerald, RM Venable, RW Pastor, ER Lyman - Biophysical Journal, 2023 - cell.com
Lipid membrane viscosity is critical to biological function. Bacterial cells grown in different
environments alter their lipid composition in order to maintain a specific viscosity, and …

Red-Emitting Pyrrolyl Squaraine Molecular Rotor Reports Variations of Plasma Membrane and Vesicular Viscosity in Fluorescence Lifetime Imaging

S Pfister, J Lesieur, P Bourdoncle, M Elhassan… - Analytical …, 2024 - ACS Publications
The viscosity that ensures the controlled diffusion of biomolecules in cells is a crucial
biophysical parameter. Consequently, fluorescent probes capable of reporting viscosity …