Branching ionizable lipids can enhance the stability, fusogenicity, and functional delivery of mRNA
K Hashiba, Y Sato, M Taguchi, S Sakamoto… - Small …, 2023 - Wiley Online Library
Ionizable lipids with branched tails have been used in lipid nanoparticles (LNPs)‐based
messenger RNA (mRNA) therapeutics like COVID‐19 vaccines. However, due to the limited …
messenger RNA (mRNA) therapeutics like COVID‐19 vaccines. However, due to the limited …
A vesicle microrheometer for high-throughput viscosity measurements of lipid and polymer membranes
Viscosity is a key property of cell membranes that controls mobility of embedded proteins
and membrane remodeling. Measuring it is challenging because existing approaches …
and membrane remodeling. Measuring it is challenging because existing approaches …
Julolidine-based Fluorescent Molecular Rotor: Versatile Tool for Sensing and Diagnose
Fluorescent molecular rotors incorporating julolidine have found diverse applications in
various fields. Recently, researchers have explored their utility in polymerization, metal ion …
various fields. Recently, researchers have explored their utility in polymerization, metal ion …
[HTML][HTML] Analytical techniques for the characterization of nanoparticles for mRNA delivery
SS Nogueira, E Samaridou, J Simon, S Frank… - European Journal of …, 2024 - Elsevier
Nanotechnology-assisted RNA delivery has gotten a tremendous boost over the last decade
and made a significant impact in the development of life-changing vaccines and …
and made a significant impact in the development of life-changing vaccines and …
Protein crowding and cholesterol increase cell membrane viscosity in a temperature dependent manner
B Fábián, I Vattulainen… - Journal of Chemical Theory …, 2023 - ACS Publications
Shear viscosity of lipid membranes dictates how fast lipids, proteins, and other membrane
constituents travel along the membrane and rotate around their principal axis, thus …
constituents travel along the membrane and rotate around their principal axis, thus …
[HTML][HTML] Effect of invasome composition on membrane fluidity, vesicle stability and skin interactions
IVN Cunha, AM Campos, AP Gerola, T Caon - International Journal of …, 2023 - Elsevier
Invasomes have been widely exploited to enhance the percutaneous permeation of drugs.
On the other hand, few studies have been dedicated to evaluating how their composition …
On the other hand, few studies have been dedicated to evaluating how their composition …
Can Urea and Trimethylamine-N-oxide Prevent the Pressure-Induced Phase Transition of Lipid Membrane?
A Maiti, S Daschakraborty - The Journal of Physical Chemistry B, 2022 - ACS Publications
Organisms dwelling in ocean trenches are exposed to the high hydrostatic pressure of
ocean water. Increasing pressure can alter the membrane packing density and fluidity and …
ocean water. Increasing pressure can alter the membrane packing density and fluidity and …
How Do Urea and Trimethylamine N-Oxide Influence the Dehydration-Induced Phase Transition of a Lipid Membrane?
A Maiti, S Daschakraborty - The Journal of Physical Chemistry B, 2021 - ACS Publications
Living organisms are often exposed to extreme dehydration, which is detrimental to the
structure and function of the cell membrane. The lipid membrane undergoes fluid-to-gel …
structure and function of the cell membrane. The lipid membrane undergoes fluid-to-gel …
Surface viscosities of lipid bilayers determined from equilibrium molecular dynamics simulations
Lipid membrane viscosity is critical to biological function. Bacterial cells grown in different
environments alter their lipid composition in order to maintain a specific viscosity, and …
environments alter their lipid composition in order to maintain a specific viscosity, and …
Red-Emitting Pyrrolyl Squaraine Molecular Rotor Reports Variations of Plasma Membrane and Vesicular Viscosity in Fluorescence Lifetime Imaging
S Pfister, J Lesieur, P Bourdoncle, M Elhassan… - Analytical …, 2024 - ACS Publications
The viscosity that ensures the controlled diffusion of biomolecules in cells is a crucial
biophysical parameter. Consequently, fluorescent probes capable of reporting viscosity …
biophysical parameter. Consequently, fluorescent probes capable of reporting viscosity …