Membranes under the magnetic lens: a dive into the diverse world of membrane protein structures using Cryo-EM
Membrane proteins are highly diverse in both structure and function and can, therefore,
present different challenges for structure determination. They are biologically important for …
present different challenges for structure determination. They are biologically important for …
Lipid membrane mimetics in functional and structural studies of integral membrane proteins
Integral membrane proteins (IMPs) fulfill important physiological functions by providing cell–
environment, cell–cell and virus–host communication; nutrients intake; export of toxic …
environment, cell–cell and virus–host communication; nutrients intake; export of toxic …
Structural insights into the lipid and ligand regulation of serotonin receptors
Abstract Serotonin, or 5-hydroxytryptamine (5-HT), is an important neurotransmitter, that
activates the largest subtype family of G-protein-coupled receptors. Drugs that target 5 …
activates the largest subtype family of G-protein-coupled receptors. Drugs that target 5 …
Structural basis of ligand recognition at the human MT1 melatonin receptor
Abstract Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone that maintains
circadian rhythms by synchronization to environmental cues and is involved in diverse …
circadian rhythms by synchronization to environmental cues and is involved in diverse …
The ABC transporter MsbA adopts the wide inward-open conformation in E. coli cells
Membrane proteins are currently investigated after detergent extraction from native cellular
membranes and reconstitution into artificial liposomes or nanodiscs, thereby removing them …
membranes and reconstitution into artificial liposomes or nanodiscs, thereby removing them …
[PDF][PDF] Recent advances in membrane mimetics for membrane protein research
JW Young - Biochemical Society Transactions, 2023 - portlandpress.com
Membrane proteins are a highly relevant class of biological molecules and comprise∼ 60%
of current drug targets. Before being analyzed by structural, biochemical, and biophysical …
of current drug targets. Before being analyzed by structural, biochemical, and biophysical …
Regulation of the cell division hydrolase RipC by the FtsEX system in Mycobacterium tuberculosis
J Li, X Xu, J Shi, JA Hermoso, LT Sham… - Nature communications, 2023 - nature.com
The FtsEX complex regulates, directly or via a protein mediator depending on bacterial
genera, peptidoglycan degradation for cell division. In mycobacteria and Gram-positive …
genera, peptidoglycan degradation for cell division. In mycobacteria and Gram-positive …
Mechanosensitive channel gating by delipidation
VJ Flegler, A Rasmussen, K Borbil… - Proceedings of the …, 2021 - National Acad Sciences
The mechanosensitive channel of small conductance (MscS) protects bacteria against
hypoosmotic shock. It can sense the tension in the surrounding membrane and releases …
hypoosmotic shock. It can sense the tension in the surrounding membrane and releases …
Structures of channelrhodopsin paralogs in peptidiscs explain their contrasting K+ and Na+ selectivities
Kalium channelrhodopsin 1 from Hyphochytrium catenoides (Hc KCR1) is a light-gated
channel used for optogenetic silencing of mammalian neurons. It selects K+ over Na+ in the …
channel used for optogenetic silencing of mammalian neurons. It selects K+ over Na+ in the …
Current problems and future avenues in proteoliposome research
AM Amati, S Graf, S Deutschmann… - Biochemical Society …, 2020 - portlandpress.com
Membrane proteins (MPs) are the gatekeepers between different biological compartments
separated by lipid bilayers. Being receptors, channels, transporters, or primary pumps, they …
separated by lipid bilayers. Being receptors, channels, transporters, or primary pumps, they …