Despite the ever-increasing prevalence of non-alcoholic fatty liver disease (NAFLD), the
etiology and pathogenesis remain poorly understood. This is due, in part, to the liver's …

Hepatocytes are the main workers in the hepatic factory, managing metabolism of nutrients
and xenobiotics, production and recycling of proteins, and glucose and lipid homeostasis …

The liver carries a remarkable ability to regenerate rapidly after acute zonal damage. Single-
cell approaches are necessary to study this process, given the spatial heterogeneity of liver …

The concept of hepatocyte functional zonation is well established, with differences in
metabolism and xenobiotic processing determined by multiple factors including oxygen and …

After severe heart injury, fibroblasts are activated and proliferate excessively to form
scarring, leading to decreased cardiac function and eventually heart failure. It is unknown …

Mammals have limited regenerative capacity, whereas some vertebrates, like fish and
salamanders, are able to regenerate their organs efficiently. The regeneration in these …

The liver controls the systemic exposure of amino acids entering via the gastro-intestinal
tract. For most amino acids except branched chain amino acids, hepatic uptake is very …

Senescent cells have long been associated with deleterious effects in aging-related
pathologies, although recent studies have uncovered their beneficial roles in certain …

Aging increases the risk of liver diseases and systemic susceptibility to aging-related
diseases. However, cell type-specific changes and the underlying mechanism of liver aging …

The impact of liver metastases on immune checkpoint-inhibitor effectiveness in patients with
solid-tumor malignancies has been the focus of several recent clinical and translational …