Improvement of the sensitivity of lateral flow systems for detecting mycotoxins: Up‐to‐date strategies and future perspectives

Z Li, A Jallow, S Nidiaye, Y Huang… - … Reviews in Food …, 2024 - Wiley Online Library
Mycotoxins are dangerous human and animal health‐threatening secondary fungal
metabolites that can be found in various food and agricultural products. Several countries …

[HTML][HTML] Structural Insights into Protein–Aptamer Recognitions Emerged from Experimental and Computational Studies

R Troisi, N Balasco, I Autiero, L Vitagliano… - International Journal of …, 2023 - mdpi.com
Aptamers are synthetic nucleic acids that are developed to target with high affinity and
specificity chemical entities ranging from single ions to macromolecules and present a wide …

Amplification-free ratiometric electrochemical aptasensor for point-of-care detection of therapeutic monoclonal antibodies

J Wan, Y Liang, Q Hu, Z Liang, W Feng, Y Tian… - Analytical …, 2023 - ACS Publications
The rapid quantification of therapeutic monoclonal antibodies (mAbs) is of great significance
to their pharmacokinetics/pharmacodynamics (PK/PD) research and the personalized …

A novel ratiometric electrochemical aptasensor based on M-shaped functional DNA complexes for simultaneous detection of trace lead and mercury ions in series …

X Wang, M Xu, Y Kuang, X Liu, J Yuan - Journal of Hazardous Materials, 2024 - Elsevier
Simultaneous quantification of multiple heavy metal ions (HMIs) is essential due to
enhanced toxicity induced by synergistic effects. The currently available detection methods …

Rapid isolation of anti-idiotype aptamers for quantification of human monoclonal antibodies against SARS-CoV-2 spike protein

K Wen, W Dai, X Meng, Q Lin, J Wei, L Tong… - Biosensors and …, 2024 - Elsevier
Therapeutic antibodies that block viral entry have already proven to be important, first line
drugs for treatments of viral infections. In the case of SARS-CoV-2, combinations of multiple …

One-step high-throughput detection of low-abundance biomarker BDNF using a biolayer interferometry-based 3D aptasensor

S Gao, Q Li, S Zhang, X Sun, X Zheng, H Qian… - Biosensors and …, 2022 - Elsevier
Although biosensors for signal monitoring have been extensively developed, their
application in one-step high-throughput detection of low-abundance disease biomarkers …

Structure-based investigation of a DNA aptamer targeting PTK7 reveals an intricate 3D fold guiding functional optimization

A He, L Wan, Y Zhang, Z Yan, P Guo, D Han… - Proceedings of the …, 2024 - pnas.org
DNA aptamers have emerged as novel molecular tools in disease theranostics owing to
their high binding affinity and specificity for protein targets, which rely on their ability to fold …

[HTML][HTML] Development of an anti-idiotype aptamer-based electrochemical sensor for a humanized therapeutic antibody monitoring

M Nagata, J Lee, T Saito, K Ikebukuro… - International Journal of …, 2023 - mdpi.com
Therapeutic monoclonal antibodies (mAbs) are currently the most effective medicines for a
wide range of diseases. Therefore, it is expected that easy and rapid measurement of mAbs …

[HTML][HTML] Monoclonal antibodies (mAbs) optical detection by coupling innovative imprinted biopolymers and magnetic beads: The case of therapeutic mAb anti …

F Torrini, F Battaglia, D Sestaioni, P Palladino… - Sensors and Actuators B …, 2023 - Elsevier
Immunotherapy has revolutionized modern medicine, becoming the largest part of the
growing bio-drugs market. Along with the progress in this direction, the need for reliable …

Site-Directed Electrochemical Grafting for Amplified Detection of Antibody Pharmaceuticals

J Wan, Y Tian, D Wu, Z Ye, S Chen, Q Hu… - Analytical …, 2024 - ACS Publications
Antibody pharmaceuticals have become the most popular immunotherapeutic drugs and are
often administered with low serum drug dosages. Hence, the development of a highly …