Mitochondrial oxidative stress in the tumor microenvironment and cancer immunoescape: foe or friend?

CL Kuo, A Ponneri Babuharisankar, YC Lin… - Journal of biomedical …, 2022 - Springer
The major concept of" oxidative stress" is an excess elevated level of reactive oxygen
species (ROS) which are generated from vigorous metabolism and consumption of oxygen …

Paclitaxel's mechanistic and clinical effects on breast cancer

TM Abu Samaan, M Samec, A Liskova, P Kubatka… - Biomolecules, 2019 - mdpi.com
Paclitaxel (PTX), the most widely used anticancer drug, is applied for the treatment of
various types of malignant diseases. Mechanisms of PTX action represent several ways in …

[HTML][HTML] Biological effects and medical applications of infrared radiation

SR Tsai, MR Hamblin - Journal of Photochemistry and Photobiology B …, 2017 - Elsevier
Infrared (IR) radiation is electromagnetic radiation with wavelengths between 760 nm and
100,000 nm. Low-level light therapy (LLLT) or photobiomodulation (PBM) therapy generally …

The mitochondrial permeability transition pore: channel formation by F-ATP synthase, integration in signal transduction, and role in pathophysiology

P Bernardi, A Rasola, M Forte… - Physiological …, 2015 - journals.physiology.org
The mitochondrial permeability transition (PT) is a permeability increase of the inner
mitochondrial membrane mediated by a channel, the permeability transition pore (PTP) …

Cardiotoxicity of anticancer drugs: Molecular mechanisms and strategies for cardioprotection

MB Morelli, C Bongiovanni, S Da Pra… - Frontiers in …, 2022 - frontiersin.org
Chemotherapy and targeted therapies have significantly improved the prognosis of
oncology patients. However, these antineoplastic treatments may also induce adverse …

Oxidative stress in the tumor microenvironment and its relevance to cancer immunotherapy

NS Aboelella, C Brandle, T Kim, ZC Ding, G Zhou - Cancers, 2021 - mdpi.com
Simple Summary Cancer cells are consistently under oxidative stress, as reflected by
elevated basal level of reactive oxygen species (ROS), due to increased metabolism driven …

Chemopreventive effects of hesperidin against paclitaxel-induced hepatotoxicity and nephrotoxicity via amendment of Nrf2/HO-1 and caspase-3/Bax/Bcl-2 signaling …

C Gur, FM Kandemir, C Caglayan, E Satıcı - Chemico-biological …, 2022 - Elsevier
Paclitaxel (PTX) is a widely used chemotherapeutic drug particularly effective against lung,
breast, and ovarian cancer, though its usefulness is limited due to its multi-organ toxicity …

Pathogenesis of paclitaxel-induced peripheral neuropathy: A current review of in vitro and in vivo findings using rodent and human model systems

NP Staff, JC Fehrenbacher, M Caillaud, MI Damaj… - Experimental …, 2020 - Elsevier
Abstract Paclitaxel (Brand name Taxol) is widely used in the treatment of common cancers
like breast, ovarian and lung cancer. Although highly effective in blocking tumor progression …

[HTML][HTML] Emerging role of NRF2 in ROS-mediated tumor chemoresistance

D Xue, X Zhou, J Qiu - Biomedicine & pharmacotherapy, 2020 - Elsevier
Chemoresistance is a central cause for the tumor management failure. Cancer cells disrupt
the redox homeostasis through reactive oxygen species (ROS) regulatory mechanisms …

Mechanisms in cancer-chemotherapeutic drugs-induced peripheral neuropathy

AS Jaggi, N Singh - Toxicology, 2012 - Elsevier
Anti-cancer drugs such as vincristine, paclitaxel, oxaliplatin, cisplatin and bortezomib are
well reported to exert direct and indirect effects on sensory nerves to alter the amplitude of …