Despite the recent increase in the development of antivirals and antibiotics, antimicrobial
resistance and the lack of broad-spectrum virus-targeting drugs are still important issues and …

Major epidemics, including some that qualify as pandemics, such as severe acute
respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), HIV, influenza A …

BACKGROUND: Increasing evidence suggests that post-TB lung disease (PTLD) causes
significant morbidity and mortality. The aim of these clinical standards is to provide guidance …

Tuberculosis continues to be a major threat to global health. Cavitation is a dangerous
consequence of pulmonary tuberculosis associated with poor outcomes, treatment relapse …

Rationale Bedaquiline has been classified as a group A drug for the treatment of multidrug-
resistant tuberculosis (MDR-TB) by the World Health Organization; however, globally …

Pulmonary cavities, the hallmark of tuberculosis (TB), are characterized by high
mycobacterial load and perpetuate the spread of M. tuberculosis. The mechanism of matrix …

Lack of access to human tissues with untreated tuberculosis (TB) has forced generations of
researchers to use animal models and to adopt a paradigm that granulomas are the …

Tuberculosis (TB) remains a leading global health problem that is aggravated by emergence
of drug-resistant strains, which account for increasing number of treatment-refractory cases …

BACKGROUND Matrix metalloproteinases (MMPs) are key regulators of tissue destruction in
tuberculosis (TB) and may be targets for host-directed therapy. We conducted a phase II …

Globally, about 36.7 million people were living with HIV infection at the end of 2015. The
most frequent infection co-occurring with HIV-1 is Mycobacterium tuberculosis—374,000 …