The stalling of ribosomes during protein synthesis results in the production of truncated
polypeptides that can have deleterious effects on cells and therefore must be eliminated. In …

Mistakes are part of our world and constantly occurring. Due to transcriptional and
translational failures, genomic mutations or diverse stress conditions like oxidation or heat …

INTRODUCTION Genetic interactions occur when mutations in two or more genes combine
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …

The formation of insoluble inclusions in the cytosol and nucleus is associated with impaired
protein homeostasis and is a hallmark of several neurodegenerative diseases. Due to the …

Secretory cargo that cannot fold properly in the ER are selectively targeted for removal by a
well-studied ER-associated degradation pathway, or ERAD. In contrast, very little is known …

Nuclear proteins participate in diverse cellular processes, many of which are essential for
cell survival and viability. To maintain optimal nuclear physiology, the cell employs the …

A defining feature of eukaryotic cells is the segregation of complex biochemical processes
among different intracellular compartments. The protein targeting, translocation, and …

The diverse functions of proteins depend on their proper three-dimensional folding and
assembly. Misfolded cellular proteins can potentially harm cells by forming aggregates in …

Protein quality control (QC) pathways survey the cellular proteome to selectively recognize
and degrade faulty proteins whose accumulation can lead to various diseases. Recognition …

Maintaining the essential functions of mitochondria requires mechanisms to recognize and
remove misfolded proteins. However, quality control (QC) pathways for misfolded …