Trained immunity contribution to autoimmune and inflammatory disorders
A dysregulated immune response toward self-antigens characterizes autoimmune and
autoinflammatory (AIF) disorders. Autoantibodies or autoreactive T cells contribute to …
autoinflammatory (AIF) disorders. Autoantibodies or autoreactive T cells contribute to …
The leaky gut and the gut microbiome in sepsis–targets in research and treatment
W Chancharoenthana, S Kamolratanakul… - Clinical …, 2023 - portlandpress.com
Both a leaky gut (a barrier defect of the intestinal surface) and gut dysbiosis (a change in the
intestinal microbial population) are intrinsic to sepsis. While sepsis itself can cause …
intestinal microbial population) are intrinsic to sepsis. While sepsis itself can cause …
Macrophage depletion alters bacterial gut microbiota partly through fungal overgrowth in feces that worsens cecal ligation and puncture sepsis mice
P Hiengrach, W Panpetch, A Chindamporn… - Scientific reports, 2022 - nature.com
Because macrophage dysfunction from some emerging therapies might worsen gut-derived
sepsis, cecal ligation and puncture (CLP) sepsis are performed in mice with clodronate …
sepsis, cecal ligation and puncture (CLP) sepsis are performed in mice with clodronate …
The emerging role of neutrophilic extracellular traps in intestinal disease
Neutrophil extracellular traps (NETs) are extracellular reticular fibrillar structures composed
of DNA, histones, granulins and cytoplasmic proteins that are delivered externally by …
of DNA, histones, granulins and cytoplasmic proteins that are delivered externally by …
Antibody Fc-receptor FcεR1γ stabilizes cell surface receptors in group 3 innate lymphoid cells and promotes anti-infection immunity
C Huang, W Zhu, Q Li, Y Lei, X Chen, S Liu… - Nature …, 2024 - nature.com
Group 3 innate lymphoid cells (ILC3) are crucial for maintaining mucosal homeostasis and
regulating inflammatory diseases, but the molecular mechanisms governing their phenotype …
regulating inflammatory diseases, but the molecular mechanisms governing their phenotype …
Training vs. Tolerance: the yin/yang of the innate immune system
For almost nearly a century, memory functions have been attributed only to acquired
immune cells. Lately, this paradigm has been challenged by an increasing number of …
immune cells. Lately, this paradigm has been challenged by an increasing number of …
Neutrophil extracellular traps in severe SARS-CoV-2 infection: A possible impact of LPS and (1→ 3)-β-d-glucan in blood from gut translocation
S Saithong, N Worasilchai, W Saisorn… - Cells, 2022 - mdpi.com
Due to limited data on the link between gut barrier defects (leaky gut) and neutrophil
extracellular traps (NETs) in coronavirus disease 2019 (COVID-19), blood samples of …
extracellular traps (NETs) in coronavirus disease 2019 (COVID-19), blood samples of …
Helicobacter pylori, Protected from Antibiotics and Stresses Inside Candida albicans Vacuoles, Cause Gastritis in Mice
P Hiengrach, W Panpetch, A Chindamporn… - International Journal of …, 2022 - mdpi.com
Due to (i) the simultaneous presence of Helicobacter pylori (ulcer-induced bacteria) and
Candida albicans in the stomach and (ii) the possibility of prokaryotic–eukaryotic …
Candida albicans in the stomach and (ii) the possibility of prokaryotic–eukaryotic …
Obesity exacerbates lupus activity in Fc gamma receptor IIb deficient lupus mice partly through saturated fatty acid-induced gut barrier defect and systemic …
K Udompornpitak, A Charoensappakit… - Journal of innate …, 2023 - karger.com
The prevalence of obesity is increasing, and the coexistence of obesity and systemic lupus
erythematosus (lupus) is possible. A high-fat diet (HFD) was orally administered for 6 …
erythematosus (lupus) is possible. A high-fat diet (HFD) was orally administered for 6 …
Critical roles of sepsis-reshaped fecal virota in attenuating sepsis severity
W Chancharoenthana, N Sutnu… - Frontiers in …, 2022 - frontiersin.org
Because studies on all fecal organisms (bacteria, fungi, and viruses) in sepsis are rare and
bacteriophages during sepsis might have adapted against gut bacteria with possible …
bacteriophages during sepsis might have adapted against gut bacteria with possible …