Trained immunity contribution to autoimmune and inflammatory disorders

SC Funes, M Rios, A Fernández-Fierro… - Frontiers in …, 2022 - frontiersin.org
A dysregulated immune response toward self-antigens characterizes autoimmune and
autoinflammatory (AIF) disorders. Autoantibodies or autoreactive T cells contribute to …

The leaky gut and the gut microbiome in sepsis–targets in research and treatment

W Chancharoenthana, S Kamolratanakul… - Clinical …, 2023 - portlandpress.com
Both a leaky gut (a barrier defect of the intestinal surface) and gut dysbiosis (a change in the
intestinal microbial population) are intrinsic to sepsis. While sepsis itself can cause …

Macrophage depletion alters bacterial gut microbiota partly through fungal overgrowth in feces that worsens cecal ligation and puncture sepsis mice

P Hiengrach, W Panpetch, A Chindamporn… - Scientific reports, 2022 - nature.com
Because macrophage dysfunction from some emerging therapies might worsen gut-derived
sepsis, cecal ligation and puncture (CLP) sepsis are performed in mice with clodronate …

The emerging role of neutrophilic extracellular traps in intestinal disease

F Chen, Y Liu, Y Shi, J Zhang, X Liu, Z Liu, J Lv, Y Leng - Gut Pathogens, 2022 - Springer
Neutrophil extracellular traps (NETs) are extracellular reticular fibrillar structures composed
of DNA, histones, granulins and cytoplasmic proteins that are delivered externally by …

Antibody Fc-receptor FcεR1γ stabilizes cell surface receptors in group 3 innate lymphoid cells and promotes anti-infection immunity

C Huang, W Zhu, Q Li, Y Lei, X Chen, S Liu… - Nature …, 2024 - nature.com
Group 3 innate lymphoid cells (ILC3) are crucial for maintaining mucosal homeostasis and
regulating inflammatory diseases, but the molecular mechanisms governing their phenotype …

Training vs. Tolerance: the yin/yang of the innate immune system

T Lajqi, N Köstlin-Gille, R Bauer, SG Zarogiannis… - Biomedicines, 2023 - mdpi.com
For almost nearly a century, memory functions have been attributed only to acquired
immune cells. Lately, this paradigm has been challenged by an increasing number of …

Neutrophil extracellular traps in severe SARS-CoV-2 infection: A possible impact of LPS and (1→ 3)-β-d-glucan in blood from gut translocation

S Saithong, N Worasilchai, W Saisorn… - Cells, 2022 - mdpi.com
Due to limited data on the link between gut barrier defects (leaky gut) and neutrophil
extracellular traps (NETs) in coronavirus disease 2019 (COVID-19), blood samples of …

Helicobacter pylori, Protected from Antibiotics and Stresses Inside Candida albicans Vacuoles, Cause Gastritis in Mice

P Hiengrach, W Panpetch, A Chindamporn… - International Journal of …, 2022 - mdpi.com
Due to (i) the simultaneous presence of Helicobacter pylori (ulcer-induced bacteria) and
Candida albicans in the stomach and (ii) the possibility of prokaryotic–eukaryotic …

Obesity exacerbates lupus activity in Fc gamma receptor IIb deficient lupus mice partly through saturated fatty acid-induced gut barrier defect and systemic …

K Udompornpitak, A Charoensappakit… - Journal of innate …, 2023 - karger.com
The prevalence of obesity is increasing, and the coexistence of obesity and systemic lupus
erythematosus (lupus) is possible. A high-fat diet (HFD) was orally administered for 6 …

Critical roles of sepsis-reshaped fecal virota in attenuating sepsis severity

W Chancharoenthana, N Sutnu… - Frontiers in …, 2022 - frontiersin.org
Because studies on all fecal organisms (bacteria, fungi, and viruses) in sepsis are rare and
bacteriophages during sepsis might have adapted against gut bacteria with possible …