Animal models of osteoarthritis: classification, update, and measurement of outcomes

EL Kuyinu, G Narayanan, LS Nair… - Journal of orthopaedic …, 2016 - Springer
Osteoarthritis (OA) is one of the most commonly occurring forms of arthritis in the world
today. It is a debilitating chronic illness causing pain and immense discomfort to the affected …

Animal models of osteoarthritis: comparisons and key considerations

AM McCoy - Veterinary pathology, 2015 - journals.sagepub.com
Osteoarthritis (OA) is unquestionably one of the most important chronic health issues in
humans, affecting millions of individuals and costing billions of dollars annually. Despite …

GRE T2 *‐Weighted MRI: Principles and Clinical Applications

MY Tang, TW Chen, XM Zhang… - BioMed research …, 2014 - Wiley Online Library
The sequence of a multiecho gradient recalled echo (GRE) T2*‐weighted imaging (T2* WI)
is a relatively new magnetic resonance imaging (MRI) technique. In contrast to T2 relaxation …

New imaging tools for mouse models of osteoarthritis

S Drevet, B Favier, B Lardy, G Gavazzi, E Brun - GeroScience, 2022 - Springer
Osteoarthritis (OA) is a chronic degenerative disease characterized by a disruption of
articular joint cartilage homeostasis. Mice are the most commonly used models to study OA …

Bone marrow lesions: plugging the holes in our knowledge using animal models

RT Hansen, C Chenu, N Sofat… - Nature Reviews …, 2023 - nature.com
Bone marrow lesions (BMLs), which are early signs of osteoarthritis (OA) that are associated
with the presence, onset and severity of pain, represent an emerging imaging biomarker and …

Inflammation and subsequent nociceptor sensitization in the bone marrow are involved in an animal model of osteoarthritis pain

T Murakami, T Ishida, S Tanaka, J Nakayama… - Life Sciences, 2023 - Elsevier
Aims This study aimed to determine whether pathological changes in the bone marrow
cause Osteoarthritis (OA) pain based on magnetic resonance imaging (MRI) …

In Vivo Cellular Infiltration and Remodeling in a Decellularized Ovine Osteochondral Allograft

T Novak, K Fites Gilliland, X Xu, L Worke… - … Engineering Part A, 2016 - liebertpub.com
Interest in decellularized tissues has steadily gained as potential solutions for degenerative
diseases and traumatic events, replacing sites of missing tissue, and providing the relevant …

A musculoskeletal finite element model of rat knee joint for evaluating cartilage biomechanics during gait

GA Orozco, K Karjalainen, EK Moo… - PLoS computational …, 2022 - journals.plos.org
Abnormal loading of the knee due to injuries or obesity is thought to contribute to the
development of osteoarthritis (OA). Small animal models have been used for studying OA …

Effect of Partial H2OD2O Replacement on the Anisotropy of Transverse Proton Spin Relaxation in Bovine Articular Cartilage

S Tadimalla, KI Momot - PLoS One, 2014 - journals.plos.org
Anisotropy of transverse proton spin relaxation in collagen-rich tissues like cartilage and
tendon is a well-known phenomenon that manifests itself as the “magic-angle” effect in …

Ultrashort time to echo magnetic resonance evaluation of calcium pyrophosphate crystal deposition in human menisci

T Finkenstaedt, R Biswas, NA Abeydeera… - Investigative …, 2019 - journals.lww.com
Objectives In human menisci, we aimed to investigate whether calcium pyrophosphate
crystal deposition (CPPD) affects biomechanical and quantitative MR properties, and their …