Impaired protein homeostasis and accumulation of damaged or abnormally modified protein
are common disease mechanisms in many neurodegenerative disorders, including …

Autophagy is a conserved pathway that delivers cytoplasmic contents to the lysosome for
degradation. Here we consider its roles in neuronal health and disease. We review …

Understanding the function of genes mutated in hereditary forms of Parkinson's disease
yields insight into disease etiology and reveals new pathways in cell biology. Although …

Parkinson's disease (PD) is a neurodegenerative disorder that affects about 1.5% of the
global population over 65 years of age. A hallmark feature of PD is the degeneration of the …

Parkinson's disease (PD) is a neurodegenerative disease caused by the loss of
dopaminergic neurons in the substantia nigra. PARK2 mutations cause early-onset forms of …

Mitochondrial dynamics and mitophagy have been linked to cardiovascular and
neurodegenerative diseases. Here, we demonstrate that the mitochondrial division dynamin …

Mitochondrial quality control is central for maintaining a healthy population of mitochondria.
Two Parkinson's disease genes, mitochondrial kinase PINK1 and ubiquitin ligase Parkin …

Parkinson's disease (PD) is a progressive neurodegenerative disorder that is characterized
by the degeneration of dopamine (DA) and non-DA neurons, the almost uniform presence of …

It has been only 15 years since studies began on the molecular mechanisms underlying
mitochondrial fission and fusion using simple model organisms such as Drosophila, yeast …

The rotarod test is widely used to evaluate the motor coordination of rodents, and is
especially sensitive in detecting cerebellar dysfunction. However, mice with striatal …