New treatment addressing the pathogenesis of psoriasis

M Tokuyama, T Mabuchi - International journal of molecular sciences, 2020 - mdpi.com
Psoriasis is an immune cell-mediated inflammatory skin disease. The interleukin (IL) 23/IL17
axis plays an important role in the development of psoriasis. The effectiveness of biologic …

Disease modification in inflammatory skin disorders: opportunities and challenges

T Bieber - Nature Reviews Drug Discovery, 2023 - nature.com
Progress in understanding of the mechanisms underlying chronic inflammatory skin
disorders, such as atopic dermatitis and psoriasis vulgaris, has led to new treatment options …

Unmet medical needs in chronic, non-communicable inflammatory skin diseases

H Ujiie, D Rosmarin, MP Schön, S Ständer… - Frontiers in …, 2022 - frontiersin.org
An estimated 20–25% of the population is affected by chronic, non-communicable
inflammatory skin diseases. Chronic skin inflammation has many causes. Among the most …

Psoriasis: comorbidities

F Yamazaki - The Journal of dermatology, 2021 - Wiley Online Library
Psoriasis has long been known as a disease with many complications, but was attributed to
diet and obesity. However, in recent years, psoriasis itself has been recognized as a series …

Immunology of psoriasis

MA Lowes, M Suarez-Farinas… - Annual review of …, 2014 - annualreviews.org
The skin is the front line of defense against insult and injury and contains many epidermal
and immune elements that comprise the skin-associated lymphoid tissue (SALT). The …

Systemic inflammation and cardiovascular comorbidity in psoriasis patients: causes and consequences

WH Boehncke - Frontiers in immunology, 2018 - frontiersin.org
Psoriasis is a common inflammatory skin disease characterized by the appearance of red
scaly plaques that can affect any part of the body. High prevalence, chronicity, disfiguration …

Efficacy and safety of biologics for psoriasis and psoriatic arthritis and their impact on comorbidities: a literature review

M Kamata, Y Tada - International journal of molecular sciences, 2020 - mdpi.com
Psoriasis is a chronic inflammatory skin disease characterized by scaly indurated erythema.
It impairs patients' quality of life enormously. It has been recognized not only as a skin …

Shared genetic risk factors and causal association between psoriasis and coronary artery disease

MT Patrick, Q Li, R Wasikowski, N Mehta… - Nature …, 2022 - nature.com
Psoriasis and coronary artery disease (CAD) are related comorbidities that are well
established, but whether a genetic basis underlies this is not well studied. We apply trans …

Psoriasis: from pathogenesis to targeted therapies

C Conrad, M Gilliet - Clinical reviews in allergy & immunology, 2018 - Springer
Over the last decade, the management of psoriasis has witnessed a paradigm shift. Thanks
to the increasing knowledge about the pathogenesis of psoriasis, targeted treatments with …

The concept of psoriasis as a systemic inflammation: implications for disease management

K Reich - Journal of the European Academy of Dermatology …, 2012 - Wiley Online Library
Psoriasis is a systemic, immune‐mediated disorder, characterized by inflammatory skin and
joint manifestations. A range of co‐morbidities is associated with psoriasis, including …