Interferon-γ (IFN-γ) is a pleiotropic cytokine that has long been praised as an important
effector molecule of anti-tumor immunity, capable of suppressing tumor growth through …

Several immune and immunocompetent cells, including dendritic cells, macrophages,
adipocytes, natural killer cells, T cells, and B cells, are significantly correlated with the …

Ubiquitination has emerged as a crucial mechanism that regulates signal transduction in
diverse biological processes, including different aspects of immune functions. Ubiquitination …

Interferon-gamma (IFNG) has long been implicated as a central orchestrator of antitumor
immune responses in the elimination stage of the immunoediting paradigm. However …

Improving efficacy of immune checkpoint blockade for cancer can be facilitated by
combining these agents with each other and/or with other conventional or targeted …

Tumors have evolved in various mechanisms to evade the immune system, hindering the
antitumor immune response and facilitating tumor progression. Immunotherapy has become …

Simple Summary Interferons are cytokines that play key roles in the activation of cellular
components of the immune response, such as dendritic cells, macrophages and T cells …

Genetic evolution that occurs during cancer progression enables tumour heterogeneity,
thereby fostering tumour adaptation, therapeutic resistance and metastatic potential …

Over the past decades, tumor-resident immune cells have been extensively studied to
dissect their biological functions and clinical roles. Tumor-infiltrating CD8+ T cells, because …

Abstract Poly-(ADP-ribose) polymerase inhibitors (PARPi) selectively kill breast and ovarian
cancers with defects in homologous recombination (HR) caused by BRCA1/2 mutations …