The technological landscape and applications of single-cell multi-omics

A Baysoy, Z Bai, R Satija, R Fan - Nature Reviews Molecular Cell …, 2023 - nature.com
Single-cell multi-omics technologies and methods characterize cell states and activities by
simultaneously integrating various single-modality omics methods that profile the …

An integrated cell atlas of the lung in health and disease

L Sikkema, C Ramírez-Suástegui, DC Strobl… - Nature medicine, 2023 - nature.com
Single-cell technologies have transformed our understanding of human tissues. Yet, studies
typically capture only a limited number of donors and disagree on cell type definitions …

Spatial transcriptomics: recent developments and insights in respiratory research

WJ Wang, LX Chu, LY He, MJ Zhang, KT Dang… - Military Medical …, 2023 - Springer
The respiratory system's complex cellular heterogeneity presents unique challenges to
researchers in this field. Although bulk RNA sequencing and single-cell RNA sequencing …

Population-level integration of single-cell datasets enables multi-scale analysis across samples

C De Donno, S Hediyeh-Zadeh, AA Moinfar… - Nature …, 2023 - nature.com
The increasing generation of population-level single-cell atlases has the potential to link
sample metadata with cellular data. Constructing such references requires integration of …

Integrative spatial analysis reveals a multi-layered organization of glioblastoma

AC Greenwald, NG Darnell, R Hoefflin, D Simkin… - Cell, 2024 - cell.com
Glioma contains malignant cells in diverse states. Here, we combine spatial transcriptomics,
spatial proteomics, and computational approaches to define glioma cellular states and …

Single-cell RNA sequencing reveals the developmental program underlying proximal–distal patterning of the human lung at the embryonic stage

S Cao, H Feng, H Yi, M Pan, L Lin, YS Zhang, Z Feng… - Cell Research, 2023 - nature.com
The lung is the primary respiratory organ in human, in which the proximal airway and the
distal alveoli are responsible for air conduction and gas exchange, respectively. However …

Early human lung immune cell development and its role in epithelial cell fate

JL Barnes, M Yoshida, P He, KB Worlock… - Science …, 2023 - science.org
Studies of human lung development have focused on epithelial and mesenchymal cell types
and function, but much less is known about the developing lung immune cells, even though …

Advanced methods and novel biomarkers in autoimmune diseases‑a review of the recent years progress in systemic lupus erythematosus

KA Fenton, HL Pedersen - Frontiers in Medicine, 2023 - frontiersin.org
There are several autoimmune and rheumatic diseases affecting different organs of the
human body. Multiple sclerosis (MS) mainly affects brain, rheumatoid arthritis (RA) mainly …

[HTML][HTML] Integrated single cell and unsupervised spatial transcriptomic analysis defines molecular anatomy of the human dorsolateral prefrontal cortex

L Huuki-Myers, A Spangler, N Eagles, KD Montgomery… - BioRxiv, 2023 - ncbi.nlm.nih.gov
Integrated single cell and unsupervised spatial transcriptomic analysis defines molecular
anatomy of the human dorsolateral prefrontal cortex - PMC Back to Top Skip to main content NIH …

A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex

LA Huuki-Myers, A Spangler, NJ Eagles… - Science, 2024 - science.org
The molecular organization of the human neocortex historically has been studied in the
context of its histological layers. However, emerging spatial transcriptomic technologies …