The technological landscape and applications of single-cell multi-omics
Single-cell multi-omics technologies and methods characterize cell states and activities by
simultaneously integrating various single-modality omics methods that profile the …
simultaneously integrating various single-modality omics methods that profile the …
An integrated cell atlas of the lung in health and disease
Single-cell technologies have transformed our understanding of human tissues. Yet, studies
typically capture only a limited number of donors and disagree on cell type definitions …
typically capture only a limited number of donors and disagree on cell type definitions …
Spatial transcriptomics: recent developments and insights in respiratory research
WJ Wang, LX Chu, LY He, MJ Zhang, KT Dang… - Military Medical …, 2023 - Springer
The respiratory system's complex cellular heterogeneity presents unique challenges to
researchers in this field. Although bulk RNA sequencing and single-cell RNA sequencing …
researchers in this field. Although bulk RNA sequencing and single-cell RNA sequencing …
Population-level integration of single-cell datasets enables multi-scale analysis across samples
C De Donno, S Hediyeh-Zadeh, AA Moinfar… - Nature …, 2023 - nature.com
The increasing generation of population-level single-cell atlases has the potential to link
sample metadata with cellular data. Constructing such references requires integration of …
sample metadata with cellular data. Constructing such references requires integration of …
Integrative spatial analysis reveals a multi-layered organization of glioblastoma
AC Greenwald, NG Darnell, R Hoefflin, D Simkin… - Cell, 2024 - cell.com
Glioma contains malignant cells in diverse states. Here, we combine spatial transcriptomics,
spatial proteomics, and computational approaches to define glioma cellular states and …
spatial proteomics, and computational approaches to define glioma cellular states and …
Single-cell RNA sequencing reveals the developmental program underlying proximal–distal patterning of the human lung at the embryonic stage
S Cao, H Feng, H Yi, M Pan, L Lin, YS Zhang, Z Feng… - Cell Research, 2023 - nature.com
The lung is the primary respiratory organ in human, in which the proximal airway and the
distal alveoli are responsible for air conduction and gas exchange, respectively. However …
distal alveoli are responsible for air conduction and gas exchange, respectively. However …
Early human lung immune cell development and its role in epithelial cell fate
Studies of human lung development have focused on epithelial and mesenchymal cell types
and function, but much less is known about the developing lung immune cells, even though …
and function, but much less is known about the developing lung immune cells, even though …
Advanced methods and novel biomarkers in autoimmune diseases‑a review of the recent years progress in systemic lupus erythematosus
KA Fenton, HL Pedersen - Frontiers in Medicine, 2023 - frontiersin.org
There are several autoimmune and rheumatic diseases affecting different organs of the
human body. Multiple sclerosis (MS) mainly affects brain, rheumatoid arthritis (RA) mainly …
human body. Multiple sclerosis (MS) mainly affects brain, rheumatoid arthritis (RA) mainly …
[HTML][HTML] Integrated single cell and unsupervised spatial transcriptomic analysis defines molecular anatomy of the human dorsolateral prefrontal cortex
L Huuki-Myers, A Spangler, N Eagles, KD Montgomery… - BioRxiv, 2023 - ncbi.nlm.nih.gov
Integrated single cell and unsupervised spatial transcriptomic analysis defines molecular
anatomy of the human dorsolateral prefrontal cortex - PMC Back to Top Skip to main content NIH …
anatomy of the human dorsolateral prefrontal cortex - PMC Back to Top Skip to main content NIH …
A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex
LA Huuki-Myers, A Spangler, NJ Eagles… - Science, 2024 - science.org
The molecular organization of the human neocortex historically has been studied in the
context of its histological layers. However, emerging spatial transcriptomic technologies …
context of its histological layers. However, emerging spatial transcriptomic technologies …