Stretch-activated ion channels: what are they?
F Sachs - Physiology, 2010 - journals.physiology.org
Mechanosensitive ion channels (MSCs) exist in all cells, but mechanosensitivity is a
phenotype not a genotype. Specialized mechanoreceptors such as the hair cells of the …
phenotype not a genotype. Specialized mechanoreceptors such as the hair cells of the …
Piezo channels: from structure to function
L Volkers, Y Mechioukhi, B Coste - Pflügers Archiv-European Journal of …, 2015 - Springer
Mechanotransduction is the conversion of mechanical stimuli into biological signals. It is
involved in the modulation of diverse cellular functions such as migration, proliferation …
involved in the modulation of diverse cellular functions such as migration, proliferation …
The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4
Cells can respond to mechanical stress by gating mechanosensitive ion channels (MSCs).
The cloning of Piezo1, a eukaryotic cation selective MSC, defines a new system for studying …
The cloning of Piezo1, a eukaryotic cation selective MSC, defines a new system for studying …
GsMTx4: mechanism of inhibiting mechanosensitive ion channels
GsMTx4 is a spider venom peptide that inhibits cationic mechanosensitive channels (MSCs).
It has six lysine residues that have been proposed to affect membrane binding. We …
It has six lysine residues that have been proposed to affect membrane binding. We …
Molecular diversity of spider venom
AA Vassilevski, SA Kozlov, EV Grishin - Biochemistry (Moscow), 2009 - Springer
Spider venom, a factor that has played a decisive role in the evolution of one of the most
successful groups of living organisms, is reviewed. Unique molecular diversity of venom …
successful groups of living organisms, is reviewed. Unique molecular diversity of venom …
Piezo1: properties of a cation selective mechanical channel
PA Gottlieb, F Sachs - Channels, 2012 - Taylor & Francis
Piezo ion channels have been found to be essential for mechanical responses in cells.
These channels were first shown to exist in Neuro2A cells, and the gene was identified by …
These channels were first shown to exist in Neuro2A cells, and the gene was identified by …
Molecular understanding of a potential functional link between antimicrobial and amyloid peptides
M Zhang, J Zhao, J Zheng - Soft Matter, 2014 - pubs.rsc.org
Antimicrobial and amyloid peptides do not share common sequences, typical secondary
structures, or normal biological activity but both the classes of peptides exhibit membrane …
structures, or normal biological activity but both the classes of peptides exhibit membrane …
Piezo channels and GsMTx4: Two milestones in our understanding of excitatory mechanosensitive channels and their role in pathology
TM Suchyna - Progress in biophysics and molecular biology, 2017 - Elsevier
Discovery of Piezo channels and the reporting of their sensitivity to the inhibitor GsMTx4
were important milestones in the study of non-selective cationic mechanosensitive channels …
were important milestones in the study of non-selective cationic mechanosensitive channels …
Interaction of tarantula venom peptide ProTx-II with lipid membranes is a prerequisite for its inhibition of human voltage-gated sodium channel NaV1. 7
ProTx-II is a disulfide-rich peptide toxin from tarantula venom able to inhibit the human
voltage-gated sodium channel 1.7 (hNa V 1.7), a channel reported to be involved in …
voltage-gated sodium channel 1.7 (hNa V 1.7), a channel reported to be involved in …
Tarantula toxins interact with voltage sensors within lipid membranes
M Milescu, J Vobecky, SH Roh, SH Kim… - The Journal of general …, 2007 - rupress.org
Voltage-activated ion channels are essential for electrical signaling, yet the mechanism of
voltage sensing remains under intense investigation. The voltage-sensor paddle is a crucial …
voltage sensing remains under intense investigation. The voltage-sensor paddle is a crucial …