Nucleolar Pol II interactome reveals TBPL1, PAF1, and Pol I at intergenic rDNA drive rRNA biogenesis
N Khosraviani, VT Yerlici, J St-Germain, YY Hou… - Nature …, 2024 - nature.com
Ribosomal DNA (rDNA) repeats harbor ribosomal RNA (rRNA) genes and intergenic
spacers (IGS). RNA polymerase (Pol) I transcribes rRNA genes yielding rRNA components …
spacers (IGS). RNA polymerase (Pol) I transcribes rRNA genes yielding rRNA components …
Looping forward: exploring R‐loop processing and therapeutic potential
Recently, there has been increasing interest in the complex relationship between
transcription and genome stability, with specific attention directed toward the physiological …
transcription and genome stability, with specific attention directed toward the physiological …
Genotoxic stress impacts pre‐mRNA 3′‐end processing
B Biswas, S Vagner - BioEssays, 2024 - Wiley Online Library
Genotoxic stress, arising from various environmental sources and endogenous cellular
processes, pose a constant threat to genomic stability. Cells have evolved intricate …
processes, pose a constant threat to genomic stability. Cells have evolved intricate …
Molecular Basis of XRN2-Deficient Cancer Cell Sensitivity to Poly (ADP-ribose) Polymerase Inhibition
T Viera, Q Abfalterer, A Neal, R Trujillo, PL Patidar - Cancers, 2024 - mdpi.com
Simple Summary Many cancers exhibit compromised 5′-3′-exoribonuclease 2 (XRN2)
expression. XRN2 is a major regulator of RNA polymerase II (RNAPII) at the transcription …
expression. XRN2 is a major regulator of RNA polymerase II (RNAPII) at the transcription …
A Recent Overview of Molecular Pathways in Synthetic Lethality as a Proposed Valid Target in Oncology: Current Insights and Future Directions
S Raja, A Rahangan, I Prabath, J Rani - Indian Journal of Surgical …, 2024 - Springer
Earlier conducted systematic reviews have focused on the important impact of synthetic
lethality (SL) application in managing various types of tumors, classifying SL, methods for …
lethality (SL) application in managing various types of tumors, classifying SL, methods for …
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
A Schreuder, K de Lint, MM Gois, RA Kampen… - bioRxiv, 2024 - biorxiv.org
With the recent rise in CRISPR/Cas9-mediated genome-wide synthetic lethality screens,
many new synthetic lethal targets have been identified for diseases with underlying genetic …
many new synthetic lethal targets have been identified for diseases with underlying genetic …
PARP1 Inhibition Preferentially Sensitizes Spliceosome Mutant Leukemias Through R-Loop-Associated Genomic Vulnerabilities
ZS Liu - 2024 - search.proquest.com
RNA splicing factor (SF) gene mutations are commonly observed in patients with myeloid
malignancies. Here, we showed that SRSF2-and U2AF1-mutant leukemias are preferentially …
malignancies. Here, we showed that SRSF2-and U2AF1-mutant leukemias are preferentially …