Human society has been burdened by psychiatric disorders throughout the course of its
history. The emergence and rapid advances of human brain organoid technology provide …

The emerging technology of brain organoids deriving from human pluripotent stem cells
provides unprecedented opportunities to study human brain development and associated …

There is a continued unmet need for treatments that can slow Parkinson's disease
progression due to the lack of understanding behind the molecular mechanisms underlying …

Accumulation of advanced glycation end products (AGEs) on biopolymers accompanies
cellular aging and drives poorly understood disease processes. Here, we studied how AGEs …

Mutations in PTEN-induced putative kinase 1 (PINK1) cause autosomal recessive early-
onset Parkinson's disease (PD). PINK1 is a Ser/Thr kinase that regulates mitochondrial …

Alphasynuclein (αsyn) aggregates are pathological features of several neurodegenerative
conditions including Parkinson disease (PD), dementia with Lewy bodies, and multiple …

Neurodegenerative diseases are a group of debilitating pathologies in which neuronal
tissue dies due to the buildup of neurotoxic plaques, resulting in detrimental effects on …

A multitude of in vitro models based on induced pluripotent stem cell (iPSC)-derived motor
neurons (MNs) have been developed to investigate the underlying causes of selective MN …

Background Variants in the CTSB gene encoding the lysosomal hydrolase cathepsin B
(catB) are associated with increased risk of Parkinson's disease (PD). However, neither the …

Lewy-body pathology with aggregation of abnormal conformations of the protein alpha-
synuclein (α-Syn) represent the histopathological hallmarks of Parkinson's disease (PD) …