Development and application of brain region–specific organoids for investigating psychiatric disorders
Human society has been burdened by psychiatric disorders throughout the course of its
history. The emergence and rapid advances of human brain organoid technology provide …
history. The emergence and rapid advances of human brain organoid technology provide …
Patterning of brain organoids derived from human pluripotent stem cells
The emerging technology of brain organoids deriving from human pluripotent stem cells
provides unprecedented opportunities to study human brain development and associated …
provides unprecedented opportunities to study human brain development and associated …
Alpha synuclein determines ferroptosis sensitivity in dopaminergic neurons via modulation of ether-phospholipid membrane composition
L Mahoney-Sanchez, H Bouchaoui, I Boussaad… - Cell reports, 2022 - cell.com
There is a continued unmet need for treatments that can slow Parkinson's disease
progression due to the lack of understanding behind the molecular mechanisms underlying …
progression due to the lack of understanding behind the molecular mechanisms underlying …
Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson's disease model
Accumulation of advanced glycation end products (AGEs) on biopolymers accompanies
cellular aging and drives poorly understood disease processes. Here, we studied how AGEs …
cellular aging and drives poorly understood disease processes. Here, we studied how AGEs …
Tom20 gates PINK1 activity and mediates its tethering of the TOM and TIM23 translocases upon mitochondrial stress
MA Eldeeb, AN Bayne, A Fallahi… - Proceedings of the …, 2024 - National Acad Sciences
Mutations in PTEN-induced putative kinase 1 (PINK1) cause autosomal recessive early-
onset Parkinson's disease (PD). PINK1 is a Ser/Thr kinase that regulates mitochondrial …
onset Parkinson's disease (PD). PINK1 is a Ser/Thr kinase that regulates mitochondrial …
Alphasynucleinassociated changes in PINK1PRKNmediated mitophagy are disease context dependent
Alphasynuclein (αsyn) aggregates are pathological features of several neurodegenerative
conditions including Parkinson disease (PD), dementia with Lewy bodies, and multiple …
conditions including Parkinson disease (PD), dementia with Lewy bodies, and multiple …
Induced pluripotent stem cells for treatment of Alzheimer's and Parkinson's diseases
DA Yefroyev, S Jin - Biomedicines, 2022 - mdpi.com
Neurodegenerative diseases are a group of debilitating pathologies in which neuronal
tissue dies due to the buildup of neurotoxic plaques, resulting in detrimental effects on …
tissue dies due to the buildup of neurotoxic plaques, resulting in detrimental effects on …
An optimized workflow to generate and characterize iPSC-derived motor neuron (MN) spheroids
MJ Castellanos-Montiel, M Chaineau… - Cells, 2023 - mdpi.com
A multitude of in vitro models based on induced pluripotent stem cell (iPSC)-derived motor
neurons (MNs) have been developed to investigate the underlying causes of selective MN …
neurons (MNs) have been developed to investigate the underlying causes of selective MN …
[HTML][HTML] The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in …
J Jones-Tabah, K He, K Senkevich… - Research …, 2023 - ncbi.nlm.nih.gov
Background Variants in the CTSB gene encoding the lysosomal hydrolase cathepsin B
(catB) are associated with increased risk of Parkinson's disease (PD). However, neither the …
(catB) are associated with increased risk of Parkinson's disease (PD). However, neither the …
Linking the phenotype of SNCA Triplication with PET-MRI imaging pattern and alpha-synuclein CSF seeding
I Wurster, C Quadalti, M Rossi, AK Hauser… - npj Parkinson's …, 2022 - nature.com
Lewy-body pathology with aggregation of abnormal conformations of the protein alpha-
synuclein (α-Syn) represent the histopathological hallmarks of Parkinson's disease (PD) …
synuclein (α-Syn) represent the histopathological hallmarks of Parkinson's disease (PD) …