DNA‐encoded chemical libraries (DECLs) are pools of DNA‐tagged small molecules that
enable facile screening and identification of bio‐macromolecule binders. The successful …

Understanding the ligandability of a target protein, defined as the capability of a protein to
bind drug‐like compounds on any site, can give important stimuli to drug‐development …

The discovery of protein ligands, capable of forming a reversible covalent bond with amino
acid residues on a protein target of interest, may represent a general strategy for the …

We describe the construction of a DNA‐encoded chemical library comprising 148 135
members, generated through the self‐assembly of two sub‐libraries, containing 265 and …

The rational combination of techniques from the fields of nanotechnology, single molecule
detection, and lead discovery could provide elegant solutions to enhance the throughput of …

DNA‐encoded libraries (DEL) have come of age and become a major technology platform
for ligand discovery in both academia and the pharmaceutical industry. Technological …

Bromodomain‐containing proteins are epigenetic modulators involved in a wide range of
cellular processes, from recruitment of transcription factors to pathological disruption of gene …