Role of copper on mitochondrial function and metabolism
Copper is essential for life processes like energy metabolism, reactive oxygen species
detoxification, iron uptake, and signaling in eukaryotic organisms. Mitochondria gather …
detoxification, iron uptake, and signaling in eukaryotic organisms. Mitochondria gather …
Recent advances on modulation of H2O2 in tumor microenvironment for enhanced cancer therapeutic efficacy
Z Chu, J Yang, W Zheng, J Sun, W Wang… - Coordination Chemistry …, 2023 - Elsevier
Due to the rapid proliferation of tumors, the hydrogen peroxide (H 2 O 2) concentration of
tumor cells is higher than that of normal cells, which can be used as an effective target for …
tumor cells is higher than that of normal cells, which can be used as an effective target for …
The glutathione peroxidase family: Discoveries and mechanism
The discoveries leading to our present understanding of the glutathione peroxidases (GPxs)
are recalled. The cytosolic GPx, now GPx1, was first described by Mills in 1957 and claimed …
are recalled. The cytosolic GPx, now GPx1, was first described by Mills in 1957 and claimed …
The multifaceted role of reactive oxygen species in tumorigenesis
Redox homeostasis is an essential requirement of the biological systems for performing
various normal cellular functions including cellular growth, differentiation, senescence …
various normal cellular functions including cellular growth, differentiation, senescence …
[HTML][HTML] Iron homeostasis and oxidative stress: An intimate relationship
Iron is a transition metal and essential constituent of almost all living cells and organisms. As
component of various metalloproteins it is involved in critical biochemical processes such as …
component of various metalloproteins it is involved in critical biochemical processes such as …
Antioxidant and Prooxidant Nanozymes: From Cellular Redox Regulation to Next‐Generation Therapeutics
Nanozymes, nanomaterials with enzyme‐mimicking activity, have attracted tremendous
interest in recent years owing to their ability to replace natural enzymes in various …
interest in recent years owing to their ability to replace natural enzymes in various …
Connecting aging biology and inflammation in the omics era
KA Walker, N Basisty, DM Wilson… - The Journal of Clinical …, 2022 - Am Soc Clin Investig
Aging is characterized by the accumulation of damage to macromolecules and cell
architecture that triggers a proinflammatory state in blood and solid tissues, termed …
architecture that triggers a proinflammatory state in blood and solid tissues, termed …
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates …
LE Tebay, H Robertson, ST Durant, SR Vitale… - Free Radical Biology …, 2015 - Elsevier
Abstract Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulates the basal and stress-
inducible expression of a battery of genes encoding key components of the glutathione …
inducible expression of a battery of genes encoding key components of the glutathione …
Biological and physiological role of reactive oxygen species–the good, the bad and the ugly
Reactive oxygen species (ROS) are chemically reactive molecules that are naturally
produced within biological systems. Research has focused extensively on revealing the …
produced within biological systems. Research has focused extensively on revealing the …
Oxidative pathways of chemical toxicity and oxidative stress biomarkers in marine organisms
F Regoli, ME Giuliani - Marine environmental research, 2014 - Elsevier
The antioxidant system of marine organisms consists of low molecular weight scavengers
and antioxidant enzymes which interact in a sophisticated network. Environmental pollutants …
and antioxidant enzymes which interact in a sophisticated network. Environmental pollutants …