Central sensitization represents an enhancement in the function of neurons and circuits in
nociceptive pathways caused by increases in membrane excitability and synaptic efficacy as …

The introduction of high-resolution time lapse imaging and molecular biological tools has
changed dramatically the rate of progress towards the understanding of the complex …

Human neuroimaging studies suggest that aberrant neural connectivity underlies
behavioural deficits in autism spectrum disorders (ASDs), but the molecular and neural …

Long lasting forms of synaptic plasticity and long-term memory formation require new mRNA
and protein synthesis. While activity-dependent expression of immediate-early genes has …

In the last years, the classical view of glial cells (in particular of astrocytes) as a simple
supportive cell for neurons has been replaced by a new vision in which glial cells are active …

Shank/ProSAP proteins are essential to synaptic formation, development, and function.
Mutations in the family of SHANK genes are strongly associated with autism spectrum …

The Homer family of adaptor proteins consists of three members in mammals, and homologs
are also known in other animals but not elsewhere. They are predominantly localized at the …

Identifying converging pathways in syndromic forms of ASD will uncover novel therapeutic
targets for non-syndromic ASD. Insights into developmental synaptopathies will lead to …

Haploinsufficiency of SHANK3, encoding the synapse scaffolding protein SHANK3, leads to
a highly penetrant form of autism spectrum disorder. How SHANK3 insufficiency affects …

Abstract SHANK3 (also called PROSAP2) genetic haploinsufficiency is thought to be the
major cause of neuropsychiatric symptoms in Phelan-McDermid syndrome (PMS). PMS is a …