It has been a decade since it was discovered that primary cilia have an essential role in
Hedgehog (Hh) signaling in mammals. This discovery came from screens in the mouse that …

The primary cilium has recently stepped into the spotlight, as a flood of data show that this
organelle has crucial roles in vertebrate development and human genetic diseases. Cilia …

Meckel-Gruber syndrome (MKS), nephronophthisis (NPHP), and related ciliopathies present
with overlapping phenotypes and display considerable allelism between at least twelve …

The Hedgehog (Hh) signalling pathway is one of the key regulators of metazoan
development. Hh proteins have been shown to play roles in many developmental processes …

In this review, anatomy and physiology of the respiratory mucosa of nose and paranasal
sinuses are summarized under the aspect of its clinical significance. Basics of endonasal …

The role of centrioles changes as a function of the cell cycle. Centrioles promote formation of
spindle poles in mitosis and act as basal bodies to assemble primary cilia in interphase …

Cilia and flagella are highly conserved eukaryotic microtubule-based organelles that
protrude from the surface of most mammalian cells. These structures require large protein …

Cilia and flagella are important organizing centers for signaling in both development and
disease. A key to their function is a poorly characterized barrier at their base that allows the …

Cilia have been implicated in Hedgehog (Hh) and Wnt signaling in mouse but not in
Drosophila. To determine whether the role of cilia is conserved in zebrafish, we generated …

Understanding how and when the left–right (LR) axis is first established is a fundamental
question in developmental biology. A popular model is that the LR axis is established …