Computational models in cardiology

SA Niederer, J Lumens, NA Trayanova - Nature reviews cardiology, 2019 - nature.com
The treatment of individual patients in cardiology practice increasingly relies on advanced
imaging, genetic screening and devices. As the amount of imaging and other diagnostic …

Application of patient-specific computational fluid dynamics in coronary and intra-cardiac flow simulations: Challenges and opportunities

L Zhong, JM Zhang, B Su, RS Tan, JC Allen… - Frontiers in …, 2018 - frontiersin.org
The emergence of new cardiac diagnostics and therapeutics of the heart has given rise to
the challenging field of virtual design and testing of technologies in a patient-specific …

The 'Digital Twin'to enable the vision of precision cardiology

J Corral-Acero, F Margara, M Marciniak… - European heart …, 2020 - academic.oup.com
Providing therapies tailored to each patient is the vision of precision medicine, enabled by
the increasing ability to capture extensive data about individual patients. In this position …

The openCARP simulation environment for cardiac electrophysiology

G Plank, A Loewe, A Neic, C Augustin… - Computer methods and …, 2021 - Elsevier
Abstract Background and Objective: Cardiac electrophysiology is a medical specialty with a
long and rich tradition of computational modeling. Nevertheless, no community standard for …

[HTML][HTML] A framework for the generation of digital twins of cardiac electrophysiology from clinical 12-leads ECGs

K Gillette, MAF Gsell, AJ Prassl, E Karabelas… - Medical image …, 2021 - Elsevier
Abstract Cardiac digital twins (Cardiac Digital Twin (CDT) s) of human electrophysiology
(Electrophysiology (EP)) are digital replicas of patient hearts derived from clinical data that …

[HTML][HTML] Electro-mechanical whole-heart digital twins: a fully coupled multi-physics approach

T Gerach, S Schuler, J Fröhlich, L Lindner… - Mathematics, 2021 - mdpi.com
Mathematical models of the human heart are evolving to become a cornerstone of precision
medicine and support clinical decision making by providing a powerful tool to understand …

[HTML][HTML] Efficient computation of electrograms and ECGs in human whole heart simulations using a reaction-eikonal model

A Neic, FO Campos, AJ Prassl, SA Niederer… - Journal of computational …, 2017 - Elsevier
Anatomically accurate and biophysically detailed bidomain models of the human heart have
proven a powerful tool for gaining quantitative insight into the links between electrical …

[HTML][HTML] 3D–0D closed-loop model for the simulation of cardiac biventricular electromechanics

R Piersanti, F Regazzoni, M Salvador, AF Corno… - Computer Methods in …, 2022 - Elsevier
Two crucial factors for accurate numerical simulations of cardiac electromechanics, which
are also essential to reproduce the synchronous activity of the heart, are:(i) accounting for …

Linking statistical shape models and simulated function in the healthy adult human heart

C Rodero, M Strocchi, M Marciniak… - PLoS computational …, 2021 - journals.plos.org
Cardiac anatomy plays a crucial role in determining cardiac function. However, there is a
poor understanding of how specific and localised anatomical changes affect different …

A rule‐based method to model myocardial fiber orientation in cardiac biventricular geometries with outflow tracts

R Doste, D Soto‐Iglesias, G Bernardino… - … journal for numerical …, 2019 - Wiley Online Library
Rule‐based methods are often used for assigning fiber orientation to cardiac anatomical
models. However, existing methods have been developed using data mostly from the left …