Epigenetic regulation of mitochondrial DNA (mtDNA) is an emerging and fast-developing
field of research. Compared to regulation of nucler DNA, mechanisms of mtDNA epigenetic …

The rediscovery and reinterpretation of the Warburg effect in the year 2000 occulted for
almost a decade the key functions exerted by mitochondria in cancer cells. Until recent …

Several mutations in nuclear genes encoding for mitochondrial components have been
associated with an increased cancer risk or are even causative, eg succinate …

Mitochondria from normal and cancerous cells represent a tale of two cities, wherein both
execute similar processes but with different cellular and molecular effects. Given the number …

Mitochondrial (MT) dysfunction has been associated with several neurodegenerative
diseases including Alzheimer's disease (AD). While MT-copy number differences have been …

Cancer is a heterogeneous group of diseases, the progression of which demands an
accumulation of genetic mutations and epigenetic alterations of the human nuclear genome …

In the last decade, mitochondrial DNA (mtDNA) haplogroups have been associated with the
occurrence of breast cancer. However, the underlying mechanism is not known. Combining …

High lactate production in cells during growth under oxygen-rich conditions (aerobic
glycolysis) is a hallmark of tumor cells, indicating the role of mitochondrial function in …

A breakthrough article published in PNAS by Luo et al. challenges a central dogma in
biology which states that the mitochondrial DNA (mtDNA) in humans is inherited exclusively …

Background Uruguay exhibits one of the highest rates of breast cancer in Latin America,
similar to those of developed nations, the reasons for which are not completely understood …