Organismal ageing is accompanied by progressive loss of cellular function and systemic
deterioration of multiple tissues, leading to impaired function and increased vulnerability to …

Post-translational modification of lysine residues via reversible acylation occurs on proteins
from diverse pathways, functions, and organisms. While nuclear protein acylation reflects the …

Since the beginning of the century, the mammalian sirtuin protein family (comprising SIRT1–
SIRT7) has received much attention for its regulatory role, mainly in metabolism and ageing …

Sirtuins are NAD+-dependent protein deacylases that regulate several aspects of
metabolism and aging. In contrast to the other mammalian sirtuins, the primary enzymatic …

Sirtuins (SIRTs) are critical enzymes that govern genome regulation, metabolism, and aging.
Despite conserved deacetylase domains, mitochondrial SIRT4 and SIRT5 have little to no …

Mesenchymal stromal/stem cells (MSCs) are multipotent stem cells present in most fetal and
adult tissues. Ex vivo culture‐expanded MSCs are being investigated for tissue repair and …

The sirtuins are a highly conserved family of NAD+-dependent enzymes that regulate
lifespan in lower organisms. Recently, the mammalian sirtuins have been connected to an …

A century after the identification of a coenzymatic activity for NAD+, NAD+ metabolism has
come into the spotlight again due to the potential therapeutic relevance of a set of enzymes …

DNA damage elicits a cellular signaling response that initiates cell cycle arrest and DNA
repair. Here, we find that DNA damage triggers a critical block in glutamine metabolism …

Aging is accompanied by a decline in the healthy function of multiple organ systems, leading
to increased incidence and mortality from diseases such as type II diabetes mellitus …