Although considered an inactive state for centuries, sleep entails many active processes
occurring at the cellular, circuit and organismal levels. Over the last decade, several key …

This review summarizes the brain mechanisms controlling sleep and wakefulness.
Wakefulness promoting systems cause low-voltage, fast activity in the …

'Nobody bewitched by these mysteries can afford to ignore the solution proposed by Mark
Solms'-Oliver Burkeman, Guardian'A remarkable book. It changes everything'-Brian Eno …

The sleep cycle is characterized by alternating non–rapid eye movement (NREM) and rapid
eye movement (REM) sleeps. The mechanisms by which this cycle is generated are …

Rapid eye movement (REM) sleep is associated with the consolidation of emotional
memories. Yet, the underlying neocortical circuits and synaptic mechanisms remain unclear …

Dopaminergic ventral tegmental area (VTA) neurons are critically involved in a variety of
behaviors that rely on heightened arousal, but whether they directly and causally control the …

Sleep disturbances frequently occur in neurodevelopmental disorders such as autism, but
the developmental role of sleep is largely unexplored, and a causal relationship between …

Ventral midbrain dopamine (DA) is unambiguously involved in motivation and behavioral
arousal, yet the contributions of other DA populations to these processes are poorly …

Humans have been fascinated by sleep for millennia. After almost a century of scientific
interrogation, significant progress has been made in understanding the neuronal regulation …

Sleep disturbance is increasingly recognized as an important, but understudied, mechanism
in the complex and multi-factorial causation of the symptoms and functional disability …