Obesity is associated with many adverse health effects, such as an increased
cardiometabolic risk. Despite higher adiposity for a given BMI, premenopausal women are at …

While most tissues exhibit their greatest growth during development, adipose tissue is
capable of additional massive expansion in adults. Adipose tissue expandability is …

Adipose tissue is a central metabolic organ. Unlike other organs, adipose tissue is
compartmentalized into individual depots and distributed throughout the body. These …

Obesity is a metabolic state generated by the expansion of adipose tissue. Adipose tissue
expansion depends on the interplay between hyperplasia and hypertrophy, and is mainly …

Healthy adipose tissue remodeling depends on the balance between de novo adipogenesis
from adipogenic progenitor cells and the hypertrophy of adipocytes. De novo adipogenesis …

The worldwide obesity epidemic makes it important to understand how lipid turnover (the
capacity to store and remove lipids) regulates adipose tissue mass. Cross-sectional studies …

Type 2 diabetes mellitus (T2DM) affects males and females disproportionately. In midlife,
more males have T2DM than females. The sex difference in T2DM prevalence is, in part …

Excessive increased adipose tissue mass in obesity is associated with numerous co-morbid
disorders including increased risk of type 2 diabetes, fatty liver disease, hypertension …

Sex differences in adipose tissue distribution and the metabolic, endocrine, and immune
functions of different anatomical fat depots have been described, but they are incompletely …

The pleiotropic function of long noncoding RNAs is well recognized, but their direct role in
governing metabolic homeostasis is less understood. Here, we describe a human adipocyte …