Beneficial and detrimental aspects of miRNAs as chief players in breast cancer: a comprehensive review

A Ismail, HA El-Mahdy, AI Abulsoud… - International Journal of …, 2023 - Elsevier
Breast cancer (BC) is the most common cancer in women and poses a serious threat to their
health. Despite familiarity with factors affecting its etiology, initiation, progression, treatment …

microRNAs orchestrate pathophysiology of breast cancer brain metastasis: advances in therapy

RK Kanchan, JA Siddiqui, S Mahapatra, SK Batra… - Molecular cancer, 2020 - Springer
Brain metastasis (BM) predominantly occurs in triple-negative (TN) and epidermal growth
factor 2 (HER2)-positive breast cancer (BC) patients, and currently, there is an unmet need …

Gene expression and miRNAs profiling: function and regulation in human epidermal growth factor receptor 2 (HER2)-positive breast cancer

RM Sareyeldin, I Gupta, I Al-Hashimi, HA Al-Thawadi… - Cancers, 2019 - mdpi.com
Breast cancer is the second most common cause of cancer-related deaths among women
worldwide. It is a heterogeneous disease with four major molecular subtypes. One of the …

miR-770-5p regulates EMT and invasion in TNBC cells by targeting DNMT3A

S Noyan, AA Ozketen, H Gurdal, BG Dedeoglu - Cellular Signalling, 2021 - Elsevier
MicroRNAs (miRNAs) are shown to regulate various processes in cancer like motility and
invasion that are key features of the metastatic triple negative breast cancer (TNBCs) …

[HTML][HTML] New insights of miRNA molecular mechanisms in breast cancer brain metastasis and therapeutic targets

BM Hussen, KH Abdullah, SR Abdullah… - Non-coding RNA …, 2023 - Elsevier
Brain metastases in breast cancer (BC) patients are often associated with a poor prognosis.
Recent studies have uncovered the critical roles of miRNAs in the initiation and progression …

[HTML][HTML] Circular RNA circ_ASAP2 promotes cell viability, migration, and invasion of gastric cancer cells by regulating the miR-770-5p/CDK6 axis

B Chen, F Ji, X Wen, Z Jin - International journal of clinical and …, 2020 - ncbi.nlm.nih.gov
Background: Gastric cancer (GC) is one of the most common causes of cancer death.
GSE83521 microarray analysis suggested that circular RNA circ_ASAP2 …

[HTML][HTML] Crosstalk between breast cancer-derived microRNAs and brain microenvironmental cells in breast cancer brain metastasis

MS Khan, GL Wong, C Zhuang, MK Najjar… - Frontiers in …, 2024 - pmc.ncbi.nlm.nih.gov
Breast cancer is the most frequent malignancy in women, constituting 15.2% of all new
cancers diagnosed in the United States. Distant breast cancer metastasis accounts for the …

[HTML][HTML] miRNAs as biomarkers of therapeutic response to HER2-targeted treatment in breast cancer: a systematic review

TH Vo, EL Esam, E Jordan, O O'Donovan… - … and Biophysics Reports, 2024 - Elsevier
Breast cancer is the most common type of lethal cancer in women globally. Women have a 1
in 8 chance of developing breast cancer in their lifetime. Among the four primary molecular …

MicroRNA: Promising roles in cancer therapy

A Hashemi, G Gorji-Bahri - Current Pharmaceutical …, 2020 - ingentaconnect.com
MicroRNAs (miRNA) are small non-coding RNAs that act as one of the main regulators of
gene expression. They are involved in maintaining a proper balance of diverse processes …

Biologicals to direct nanotherapeutics towards HER2-positive breast cancers

G Kumar, K Nandakumar, S Mutalik, CM Rao - … , Biology and Medicine, 2020 - Elsevier
HER2-positive breast cancer, an aggressive cancer, is treated with combinations of
conventional anticancer drugs viz., cytotoxic drugs, nibs, and mAbs. Major limitations …