The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

Acetyl-CoA carboxylases (ACCs) are enzymes that catalyze the carboxylation of acetyl-CoA
to produce malonyl-CoA. In mammals, ACC1 and ACC2 are two members of ACCs. ACC1 …

NAFLD is closely linked with hepatic insulin resistance. Accumulation of hepatic
diacylglycerol activates PKC-ε, impairing insulin receptor activation and insulin-stimulated …

Nonalcoholic fatty liver disease (NAFLD) is a liver manifestation of metabolic syndrome.
Overconsumption of high-fat diet (HFD) and increased intake of sugar-sweetened …

Inhibiting lipogenesis prevents hepatic steatosis in rodents with insulin resistance. To
determine if reducing lipogenesis functions similarly in humans, we developed MK-4074, a …

The obesity epidemic has led to an increased incidence of nonalcoholic fatty liver disease
(NAFLD) and type 2 diabetes. AMP-activated protein kinase (Ampk) regulates energy …

Mitochondrial dysfunction has been implicated in the development of insulin resistance (IR);
however, a large variety of association and intervention studies as well as genetic …

Simultaneous inhibition of the acetyl-CoA carboxylase (ACC) isozymes ACC1 and ACC2
results in concomitant inhibition of fatty acid synthesis and stimulation of fatty acid oxidation …

Biotin-dependent carboxylases include acetyl-CoA carboxylase (ACC), propionyl-CoA
carboxylase (PCC), 3-methylcrotonyl-CoA carboxylase (MCC), geranyl-CoA carboxylase …

Skeletal muscle plays an important role in regulating whole-body energy expenditure given
it is a major site for glucose and lipid oxidation. Obesity and type 2 diabetes are causally …