Background: Since disulfiram's discovery in the 1940s and its FDA approval for alcohol use
disorder, other indications have been investigated. This review describes potential clinical …

A growing body of evidence suggests that nucleus accumbens (NAc) plays a significant role
not only in the physiological processes associated with reward and satisfaction but also in …

Dopamine (DA) controls many vital physiological functions and is critically involved in
several neuropsychiatric disorders such as schizophrenia and attention deficit hyperactivity …

A key question in addiction research concerns how, in some individuals, initial recreational
or casual patterns of drug use may change brain and psychological function in ways that …

The temporal pattern of drug use (pharmacokinetics) has a profound effect on the ability of
self‐administered cocaine to produce addiction‐like behavior in rodents, and to change the …

Cocaine addiction is characterized by dysfunction in reward-related brain circuits, leading to
maladaptive motivation to seek and take the drug. There are currently no clinically available …

Background: Cocaine dependence is an important problem without any effective
pharmacological treatment. Some preclinical studies have suggested that cannabidiol …

Background/Objectives: Dopamine dysfunction (DA) is a hallmark of many neurological
disorders. In this case, the mechanism of changes in dopamine transmission on behavior …

A systematic review of functional neuroimaging studies on drug (self-) administration in
rodents is lacking. Here, we summarized effects of acute or chronic drug administration of …

Although the dopamine transporter (DAT) is the primary site of action for cocaine, and the
dopamine system is known to mediate the reinforcing effects of cocaine, the dopaminergic …