Heart failure (HF) has become increasingly common within the elderly population,
decreasing their survival and overall quality of life. In fact, despite the improvements in …

The insulin receptor substrate proteins IRS1 and IRS2 are key targets of the insulin receptor
tyrosine kinase and are required for hormonal control of metabolism. Tissues from insulin …

Inflammation is a key mechanism of cardiovascular diseases. It is an essential component of
atherosclerosis and a significant risk factor for the development of cardiovascular events. In …

The metabolic syndrome (MetS) is comprised of a cluster of closely related risk factors,
including visceral adiposity, insulin resistance, hypertension, high triglyceride, and low high …

G protein-coupled receptor (GPCR) kinases (GRKs) are best known for their role in
homologous desensitization of GPCRs. GRKs phosphorylate activated receptors and …

Diabetes mellitus increases the risk of heart failure independent of co-existing hypertension
and coronary artery disease. Although several molecular mechanisms for the development …

La diabetes mellitus es una enfermedad metabólica caracterizada por un defecto en la
regulación de la glucemia por la insulina. En la actualidad, la prevalencia de diabetes es …

G protein-coupled receptors (GPCRs) are important regulators of various cellular functions
via activation of intracellular signaling events. Active GPCR signaling is shut down by GPCR …

GRK2 is a ubiquitous member of the G protein‐coupled receptor kinase (GRK) family that
appears to play a central, integrative role in signal transduction cascades. GRKs participate …

G protein-coupled receptor kinase 2 (GRK2) is a central signaling node involved in the
modulation of many G protein-coupled receptors (GPCRs) and also displaying regulatory …